WANG Yubao



WANG  Yubao received his Ph.D. from the Albert Einstein College of Medicine in 2010, where he investigated the role of PI3K/Akt/mTOR signaling in the manipulation of host cell growth and survival mediated by the intracellular parasite, Toxoplasma gondii (Wang et al., JBC 2009, 2010; Cell Microbiol 2009). These studies developed into a broader examination of the multifaceted roles of these pathways in autophagy and in cell migration. His enthusiasm for studying kinases then allured him to join the laboratory of Dr. Jean Zhao at Dana-Farber Cancer Institute. His work in Jean’s lab, in close collaboration with many renowned investigators, has generated significant insights into a major type of difficult-to-treat cancer (Wang et al., eLIFE 2014; Cell 2015; PNAS 2016). Dr. Wang is currently a faculty member in the School of Life Sciences at the University of Science and Technology, Hefei, China.

Wang, Y., Begley, M., Li Q., Huang, H., Lako, L., Eck, M.J., Gray, N.S., Mitchison, T.J., Cantley, L.C. and Zhao. J.J. (2016) Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. PNAS 113, 9810-9815.

Wang, Y.*, Zhang, T.*, Kwiatkowski, N.*, Abraham, B.J., Lee, T.I., Xie. S., Yuzugullu, H., Von, T., Li, H., Lin, Z., Stover, D.G., Lim, E., Wang, Z.C., Iglehart, J.D., Young, R.A., Gray, N.S. and Zhao, J.J. (2015) CDK7-dependent transcriptional addiction in triple-negative breast cancer. Cell 163, 174-186.  (*equal contribution)

Wang, Y., Lee, Y. M., Baitsch, L., Huang, A., Xiang, Y., Tong, H., Lako. A., Von. T., Choi. C., Lim. E., Min. J., Li. L., Stegmeier. F., Schlegel. R., Eck. M.J., Gray. N.S., Mitchison. T.J. and Zhao, J. J. (2014). MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. eLife, e01763.

Wang, Y., Weiss, L.M. and Orlofsky, A. (2010). Coordinate control of host centrosome position, organelle distribution, and migratory response by Toxoplasma gondii via host mTORC2. J Biol Chem. 285, 15611-15618.

Wang, Y., Karnataki, A., Parson, M., Weiss, L.M. and Orlofsky, A. (2010). Blockade of centrosome replication and growth in Toxoplasma gondii by 3-methyladenine. Mol Biochem Parasitol. 41, 595-607.

Deng, L., Zhou, JF, Sellers, RS., Li, J., Nguyen, AV., Wang, Y., Orlofsky, A., Liu, Q., Hume, DA, Pollard, JW., Augenlicht, L. and Lin, E.Y. (2010). A novel mouse model of inflammatory bowel disease links mTOR- dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am J Pathol. 176, 952-967.

Wang, Y., Weiss, L.M. and Orlofsky, A. (2009). Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth. J Biol Chem. 284, 1694-1701.

Wang, Y., Weiss, L.M. and Orlofsky, A. (2009). Intracellular parasitism with Toxoplasma gondii stimulates mTOR-dependent host cell growth despite impaired signaling to S6K1 and 4E-BP1. Cellular Microbiology 11, 983-1000.

Wang, Y., Lou, Y., Luo. Z., Zhang. D. and Wang, Y. (2003). Induction of apoptosis and cell cycle arrest by polyvinylpyrrolidone K-30 and protective effect of α-tocopherol. Biochem. Biophy. Res. Commun.308, 878-884.