SUN Linfeng
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    SUN Linfeng


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    SUN Linfeng , Ph.D.
    Professor, School of Life Sciences
    University of Science & Technology of China
    443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
    Email: sunlf09(at)mail.tsinghua.edu.cn. (at 换成@)

    Education and Appointment:
    2017–present:  Professor, School of Life Sciences, University of Science and Technology of China (USTC)
    2014-2017: Postdoctoral Fellow (with Dr. Yigong Shi), School of Life Sciences, Tsinghua University
    2009-2014: Ph.D., School of Life Sciences, Tsinghua University
    2005-2009: B.S., Department of Biological Sciences and Biotechnology, Tsinghua University

    Honors & Awards:
    2010 Longrich, Jiangsu-Tsinghua University Scholarship in Biology
    2012 National Scholarship for graduate students
    2014 Second-rank Scholarship for PhD Thesis of Tsinghua University
    2014 Third-rank Research Scholarship of Center for Life Sciences
    2014 Top-rank Postdoctoral Fellowship of Center for Life Sciences
    2016  Advanced Innovation Fellow of the Advanced Innovation Center for Structural Biology, Tsinghua University

    Research Field of Interest:
    Mechanistic studies of important membrane proteins using structural biology techniques such as Cryo-EM 3D reconstruction and X-ray crystallography.

    Representative Publications:
    1.Sun L*, Zhou R*, Yang G*, Shi Y. (2017). Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase. Proceedings of the National Academy of Sciences of the United States of America, 114(4), E476-E485. (*, co-first author)
    2.Sun L, Li X, Shi Y. (2016). Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to γ-secretase. Current Opinion in Structural Biology, 37, 97–107.
    3.Sun L*, Zhao L*, Yang G*, Yan C*, Zhou R*, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y. (2015). Structural basis of human γ-secretase assembly. Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6003-6008. (*, co-first author)
    4.Madej MG*, Sun L*, Yan N, Kaback HR. (2014). Functional architecture of MFS D-glucose transporters. Proceedings of the National Academy of Sciences of the United States of America, 111(7), E719-727. (*, co-first author)
    5.Sun L*, Zeng X*, Yan C, Sun X, Gong X, Rao Y, Yan N. (2012). Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490(7420), 361-366. (*, co-first author)
    6.Bai XC*, Yan C*, Yang G*, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y. (2015). An atomic structure of human γ-secretase. Nature, 525(7568), 212-217. (*, co-first author)
    7.Xie T*, Yan C*, Zhou R, Zhao Y, Sun L, Yang G, Lu P, Ma D, Shi Y. (2014).  Crystal structure of the γ-secretase component nicastrin. Proceedings of the National Academy of Sciences of the United States of America, 111(37), 13349-13354. (*, co-first author)
    8.Lu P*, Bai XC*, Ma D*, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SH, Shi Y. (2014). Three-dimensional structure of human γ-secretase. Nature, 512(7513),166-170. (*, co-first author)
    9.Sugihara J, Sun L, Yan N, Kaback HR. (2012). Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14847-14851.
    10.Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N. (2010). Structure of a fucose transporter in an outward-open conformation. Nature, 467(7316), 734-738.
    11.Gao X*, Lu F*, Zhou L*, Dang S, Sun L, Li X, Wang J, Shi Y. (2009). Structure and mechanism of an amino acid antiporter. Science, 324(5934):1565-1568. (*, co-first author)

     


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