YAO Xuebiao
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    YAO Xuebiao


    Xuebiao Yao, PhD, is a Cheung Kong Professor (1998) and recipient of NSFC Outstanding Young Scientist Award (1999). He graduated, with a PhD in molecular & cell Biology, from the University of California-Berkeley in 1995 followed by a postdoctoral fellowship at the University of California-San Diego. He accepted a tenure-track assistant professorship at the University of Wisconsin-Madison in 1997. He joined the University of Science & Technology of China in 1999 to create the Laboratory for Cellular Dynamics to delineate the organelle dynamics and plasticity control underlying cell fate decision in mitosis using a palette of optical sensors and chemical modulators. The training philosophy in the Laboratory for Cellular Dynamics is to transform motivated talents into future star scientists in biomedical sciences. Many trainees from the Laboratory for Cellular Dynamics were recognized with Qing Qian Scholarship, Ray Wu Prize, CAS Outstanding Dissertation Award, Keynote speaker of Harvard graduation (2016), Damon Runyon Research Fellowshipetc.

    Dr. Yao serves on many editorial boards (Cell Res., Cell Discovery, JBC, JMCB etc) and heads the Anhui Key Laboratory for Cellular Dynamics & Chemical Biology. The active research areas in Dr. Yao’s group include: centromere plasticity & stemness control; chemical biology of mitosis & metastasis; organoids architect & plasticity control; single molecule & super-resolution imaging. The current research supports were generously provided by Chinese Academy of Sciences; Natural Science Foundation of China, Ministry of Science & Technology of China.


    Ten representative publications from a collection of more than 150:

    1. Ding, X; Yan, F; Yao, P; Yang, Z; Wan, W; Wang, X; Liu, J; Gao, X; Abrieu, A; Zhu, T; Zhang, J; Dou, Z; Yao, X. 2010. Probing CENP-E function in mitotic chromosome dynamics using small molecule inhibitor syntelin. Cell Research 20, 1386-1389.

    2. Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Xiang H, Gao F, Yu X, Liao J, Ward T, Xia P, Emenari C. Ding X, Thompson W, Ma K, Zhu J, Aikhionbare F, Dou K, Zhu J, Cheng S, and Yao X. 2011. Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Research 71, 1721-1730.

    3. Chen J, Yu F, Gong C, Yao D, Deng H, Wang F, Anderson K, Liu Q, McEwen M, Yao X*, Song E*. 2011. CCL18 from tumor associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19, 541-555; *correspondence.

    4. Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X*, Teng M*. 2012. The structure of the FANCM-MHF complex reveals physical features for functional assembly.Nature Commun. 3, 782-791.

    5. Xia P, Wang Z, Liu X, Wu B, Ward T, Zhang L, Ding X, Gibbons G, Shi Y, Yao X. 2012. EB1 acetylation by PCAF ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A. 109, 16564-9.

    6. Zhao X, Wang D, Liu X, Liu L, Song Z, Zhu T, Adams G, Gao X, Tian R, Huang Y, Chen R, Wang F, Liu D, Yu X, Chen Y, Chen Z, Teng M, Ding X, Yao X. 2013. Phosphorylation of BAR domain of ACAP4 regulates membrane tubulation. Proc Natl Acad Sci USA. 110, 11023-8.

    7. Yao X, Li D, Pei G. 2013. In focus: Molecular and Cell Biology Research in China. Nat Rev Mol Cell Biol. 14, 600-606.

    8. Xia P, Liu X, Wu B, Zhang S, Song X, Yao PY, Lippincott-Schwartz J, Yao X. 2014. Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking. Mol Biol Cell. 25, 4166-73.

    9. Dou Z, Liu X, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*.2015. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci USA.112, E4546-55

    10. Mo F, Zhuang X, Liu X*, Yao P, Qin B, Su Z, Zang J, Wang Z, Zhang J, Niu L, Hill DL, Fang G, Fu C, Yao X*. 2016. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nature Chem. Biol. 12, 226-232.  *correspondence.



    Contact:0551-63607141   yaoxb@ustc.edu.cn




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