XU Chao



Chao Xu, Ph. D

Professor, School of Life Sciences, University of Science and Technology of China

443 Huangshan Street, Hefei City, Anhui 230027, P.R.China

Tel: (+86)15665692601

E-mail: xuchaor@ustc.edu.cn


2016 Present: Professor, School of Life Sciences, University of Science & Technology of China, China

2009 – 2015: Postdoc, Structural Genomics Consortium (SGC), University of Toronto, Canada

2006 – 2008: Postdoc, Mayo Clinic College of Medicine, USA

2000 – 2005: Ph.D. Biochemistry and molecular biology, School of Life Sciences,

University of Sciences and Technology of China, China

1996 2000: B.Sc. Biology, School of Life Sciences, University of Sciences and Technology of China, China


My research focuses on disease relevant protein complexes and protein-DNA complexes in epigenetics and RNA epeignetics. Epigenetics is the study of acquired changes in chromatin structure that arise independently of a change in the underlying DNA nucleotide sequence. Modificatoins of DNA, histone and RNA regulate the eukaryotic gene expression at different layers. Abnormal regulation of gene expression lead to a number of diseases including cancer, autoimmune and neurodegenerative diseases. We utilize structural biology, molecular biology and chemical biology to explore the molecular mechanism underlining the complicated regulatory mechanisms and to identify small molecules to treat human diseases.


SELECTED PUBLICATIONS(#: corresponding author; *: Co-first author)

After 2016 (inclusive):

1. Liao, S., *Sun, H., *Xu, C.YTH Domain: A Family of N6-methyladenosine (m6A) Readers. Genomics, Proteomics & Bioinformatics. (2018). In press.

2. #Guo, Q., #*Liao, S., Zhu, Z., Li, Y., Li, F., *Xu, C. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J. Biol. Chem.293, 557-566. (2018).

3. #Xu, C., #Liu, K., Yang, A., Li, Y., Hughes, T.R., *Min, J. DNA sequence recognition of human CXXC domains and their structural determinants. Structure.26, 85-95. (2018).

4. *Xu, C., Ishikawa, H., Izumikawa, K., Li, L., He, H., Nobe, Y., Yamauchi, Y., Shahjee, M.H., Xian-Hui Wu, Yu, Y., Isobe, T., Takahashi, N., *Min, J. Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev. 30, 2376-2390. (2016).

5#Chung, H., #Xu, C., #Fuchs, A., Mund, A., Lange, M., Steage, H., Schubert, T., Bian,C., Dunkel, I., Eberharter, A., Regnard, C., Klinker, H., Meierhofer, D., Cozzuto,L., Winterpacht, A., Di Croce, L., Min, J., Will, H., *Kinkley, S. PHF13 is a Molecular Reader and Transcriptional Co-Regulator of H3K4me2/3. eLife. 5, e10607. (2016).

Before 2016

6. *#Xu, C., *Wang, X., *Liu, K., Roundtree, I., Tempel, W., Li, Y., Lu, Z., *He, C., *Min, J. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat. Chem. Biol. 10, 927-929. (2014). (Recommended by Faculty of 1000).

7. #Ni, Z., #Xu, C., Guo, X., Hunter, G., Kuznetsova, O., Tempel, W., Marcon, E., Zhong, G., Guo, H., Kuo, W., Li, J., Young, P., Olsen, J., Wan, C., Loppnau, P., Bakkouri, M., Senisterra, G., He, H., Huang, H., Sidhu, S., Emili, A., Murphy, S., Mosley, A., Arrowsmith, C., *Min, J., *Greenblatt, J. RPRD1A and RPRD1B Serve as RNA Polymerase II Carboxyl-Terminal Domain Scaffolds to Recruit RPAP2 for Serine 5 Dephosphorylation. Nat. Struct. Mol. Biol. 21, 686-695. (2014).

8.#Xu, Y., #Xu, C., #Kato, A., Tempel, W., Abreu, J.C., Bian, C.,Hu, Y., Hu, D., Zhao, B., Cerovina, T., Diao, J., Wu, F., He, H.H., Cui, Q., Clark, E., Ma, C., Barbara, A., Veenstra, G.J.C., Xu, G., Kaiser, U.B., Liu, X.S., Sugrue, S.P., He, X., *Min, J., *Kato, Y., *Shi, Y.G. Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development. Cell. 151, 1200-1213. (2012).

9. #Xu, C., #Jin, J., Bian, C., Lam, R., Tian, R., Weist, R., You, L., Nie, J., Bochkarev, A., Tempel, W., Tan, C., Wasney, G., Vedadi, M., Gish, G., Arrowsmith, C., Pawson, T., Yang, X., *Min, J. Sequence-specific Recognition of a PxLPxI/L Motif by the Ankyrin-repeat Tumbler Lock. Sci. Signal. 5, ra39. (2012). (cover article).

10. #Bian, C., #Xu,C., #Ruan, J., #Lee, K., #Burke, T., Tempel, W., Barsyte, D., Li, J., Wu, M., Zhou, B., Fleharty, B.E., Paulson, A., Allali-Hassani, A., Zhou, J., Mer, G., Grant, P., *Workman, J.L., *Zang, J., *Min, J. Structural Basis of Sgf29 Tandem Tudor Domains Selectively Binding Methylated Histone H3K4 to Regulate Enzymatic Activity of the SAGA Complex. EMBO J. 30, 2849-2842. (2011).

11. #Xu, C., #Bian, C., Lam, R., Dong, A. *Min, J. Structural Basis of Selective Binding of Nonmethylated CpG islands by the CXXC Domain of CFP1. Nat. Commun. 2: 227. (2011).

12. #Xu, C., #Bian, C., #Yang, W., Galka, M., Ouyang, H., Chen, C., Qiu, W., Liu, H., Jones, A., MacKenzie, F., Pan, P., *Li, S., *Wang, H., *Min, J. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc. Natl. Acad. Sci. 107, 19266-19271. (2010).