TIAN Changlin
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    TIAN Changlin


    Name: Changlin Tian (田长麟)
    Born: WuHan, HuBei
    Tel: 86-551-63600872(O)
    Office: Room 524, School of Life Science, USTC

    1997.09-2003.05 Ph.D. in Molecular Biophysics, Institute of Biophysics, Florida State University, Tallahassee, FL, USA
    1995.09-1997.07 M.S. in Molecular Biology, Department of Biological Science and Technology, Shanghai Jiao Tong University
    1991.09-1995.07 B.S. in Applied Electronic Technology, Department of Information Control
    B.S. in Biochemical Engineering, Department of Biological Science and Technology, Shanghai Jiao Tong University, Shanghai, P. R. China

    Working Experience and Affiliation
    2014.10-Present  Director, Division of General Administration,Hefei Science Center,Chinese Academy of Sciences
    2009.08-2014.09 Deputy Director, High Magnetic Field Laboratory, Chinese Academic of Science
    2006.11-Present Professor of Biochemistry and Molecular Biology, School of Life Science, University of Science and Technology of China, Hefei, Anhui, P. R. China
    2003.03-2007.02 Postdoctoral Research Associate, Center for Structural Biology, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    1998.01-2003.03 Research Assistant, Center for Interdisciplinary of Magnetic Resonance, National High Magnetic Field Laboratory, Tallahassee, FL, USA
    2010.04-Present Associate Director of Molecular Biophysics Committee, the Biophysical Society of China
    2008.12 Young Faculty Career Award, University of Science and Technology of China Alumni Foundation
    2007.12 Young Investigator Award, Huo-Ying-Dong Education Foundation
    2006.01-2008.12 Postdoctoral Fellowship Award, American Heart Association (stopped on 03/2006, due to resignation from Vanderbilt University)

    Working Experience and Affiliation
    2014.04-Present General Secretary of Biological Magnetic Resonance Branch, the Biophysical Society of China

    Research Interests
    Research interests in Dr. Changlin Tian’s lab is focusing on three parts:
    1)Developing biophysical methods to analyze protein-protein interactions and protein dynamic properties in-situ or in native cellular (both prokaryotic and eukaryotic) environments. The methods include nuclear magnetic resonance (NMR), electron spin resonance (ESR), fluorescence and other related spectroscopic methods.
    2)Developing chemical synthesis methods for unnatural amino acids and polypeptides.
    3)Structure and function studies of ion channels. Using the combinational structural biology methods to illustrate three dimensional structures of ion channels, modulatory subunits and/or native toxins. Using the patch-clamp methods to illustrate physiological behavior of ion channels and their functional variations under different modulatory molecules. 

    1) Structure, Dynamics and Physiology studies of Potassium Channel and its Modulation Protein
    2) Method Development of Magnetic Resonance (NMR, EPR) and combination studies with other biophysical methods

    Selected Publications:

    1.Zhong P, Li J, Luo L, Zhao Z*, Tian Z*. Top1α regulates FLOWERING LOCUS C expression by coupling histone modification and transcription machinery.Development. doi: 10.1242/dev.167841, 2019.

    2.Luo L, Zeng J, Wu H, Tian Z*, Zhao Z*. A Molecular Framework for Auxin-Controlled Homeostasis of Shoot Stem Cells in Arabidopsis. Mol Plant. 11(7), 899-913, 2018.

    3.Qu X, Zhao Z* and Tian Z*. ERECTA regulates cell elongation by activating auxin biosynthesis in Arabidopsis thaliana.Front. Plant Sci. doi: 10.3389/fpls.2017.01688, 2017 

    4.Zeng J, Dong Z, Wu H, Tian Z, Zhao Z. Redox regulation of plant stem cell fate. EMBO J. 36, 2844-2855, 2017

    5.Luo, L,  Zeng, J,  Tian, Z,  Zhao, Z. Plant development: From cells to individuals.Chinese Science Bulletin, 61(33), 3532-3540, 2016

    6.Li, W Tian Z, and Yu D. WRKY13 acts in stem development in Arabidopsis thaliana. Plant Science. 236: 205-213, 2015

    7.Cui Y1, Rao S, Chang B, Wang X, Zhang K, Hou X, Zhu X, Wu H, Tian Z, Zhao Z, Yang C, Huang T. AtLa1 protein initiates IRES-dependent translation of WUSCHEL mRNA and regulates the stem cell homeostasis of Arabidopsis in response to environmental hazards. Plant Cell Environ. 38 (10), 2098-2114, 2015

    8.Weng L, Tian Z, Feng XZ, Li X, Xu S, Luo D and Yang J. Petal Development in Lotus japonicas.Journal of Integrative Plant Biology, 53(10): 770-782, 2011

    9.Wang J, Tian Z, Zhao Z, Luo D, Hu X. Mutations Affecting Lateral Petal Development in Lotus japonicus.

    Molecular Plant Breeding, 8 (1), 6-10, 2010.

    10.Didiot MC*, Tian Z*, Schaeffer C, Subramanian M, Mandel JL, Moine H. The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer.Nucleic Acids Res. 36(15): 4902-4912, 2008. (*co-first authors). Nucleic Acids Res. 36(15): 4902-4912, 2008. (*co-first authors).

    11.Feng X*, Zhao Z*, Tian Z*, Xu S, Luo Y, Cai Z, Wang Y, Yang J, Wang Z, Weng L, Chen J, Zheng L, Guo X, Luo J, Sato S, Tabata S, Ma W, Cao X, Hu X, Sun C, Luo D. Control of petal shape and floral zygomorphy in Lotus japonicus. Proc Natl Acad Sci U S A. 103(13): 4970-4975, 2006. (*co-first authors).

    12.Book chapter:

    Schaeffer C, Didiot MC, Tian Z, Bernard Ehresmann B, Ehresmann C and Moine H. FMRP and the G-quartets, in The Molecular Basis of Fragile X Syndrome, Editors: Ying Ju Sung and Robert B. Denman, ISBN: 81-7736-257-7


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