ZHANG Huafeng
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    ZHANG Huafeng



    Huafeng Zhang (张华凤), Professor, School of Life Sciences, USTC,
    443 Huangshan Road, Hefei 230027, China
    Tel: 86-551-63607131(O) and 86-551-3607012(lab)
    Homepage: http://staff.ustc.edu.cn/~hzhang22/index.html

    Personal Profile
    Dr. Huafeng Zhang obtained Ph. D degree from University of Tokyo in Japan in 2004. She went on for her postdoctoral study in National Cancer Institute of NIH from 2004 to 2005, studying protein dynamics. From 2005 to 2010, she worked in the laboratory of Dr. Gregg Semenza in Johns Hopkins University to study hypoxia and cancer development. Her major achievements include multiple highly-cited papers in the field of cancer research. She has published more than 40 research papers that are cited more than 3000 times by peer scientists. She is also joint-appointed as a faculty member at Division of Bio-X Interdisciplinary Sciences, Hefei National Laboratory for Physical Science at Microscale.

    Research Interests
    1.Tumor microenvironment and metabolism
    2.Tumor microenvironment and metastasis
    3.Epigenetic changes in tumor development
    4.Screening and developing new anti-cancer molecules for cancer therapy

    Selected Publications 

    1. Li ST, Huang D, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X*, Zhang H*, Gao P*. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism, 2020 March 16; 2:256-269.

    2. Xing S, Li Z, Ma W, He X, Shen S, Wei H, Li ST, Shu Y, Sun L, Zhong X, Huangfu Y, Su L, Feng J, Zhang X, Gao P, Jia WD, Zhang H. DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing. Cancer Res. 2019 Oct 1;79(19):4923-4936.

    3. Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H. Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Rep. 2019 Oct 4;20(10):e48115. doi: 10.15252/embr.201948115.

    4. Liu X, Shen S, Wu P, Li F, Liu X, Wang C, Gong Q, Wu J, Yao X, Zhang H*, Shi Y*. Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res. 2019 Aug 22;47(14):7648-7665.

    5. Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H*, Zhou Q*, Gao P*. Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells. Cell Metabolism 2019 Apr 2;29(4):979-992.

    6. Xiaoyu Ma, Lin Wang, De Huang, Yunyan Li, Dongdong Yang, Junfeng Wang, Ping Gao and Zhang H. Polo-like Kinase 1 Coordinates Biosynthesis during Cell Cycle Progression by Directly activating. Pentose phosphate pathway. Nature Communications 2017 Nov 15;8(1):1506.

    7. Huang D, Li T, Wang L, Zhang L, Yan R, Kui Li, Xing S, Wu G, Hu L, Jia W, Lin S, Dang CV, Song L, Gao P, Zhang H. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition stress. Cell Research 2016 Sep 20. 26(10), 1112-1130.

    8. Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Wang Y, Gao P*, Tang H, Zhang H. cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation  Conditions. Cell Research 2015 Apr;25(4):429-44.

    9. Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications 2014 Oct 10;5:5212.

    10. Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H. HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports 2014 Sep 25;8(6):1930-42 .

    11. Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Dang CV, Semenza GL. HIF-1 represses mitochondrial mass and respiration in VHL-null renal cell carcinoma. Cancer Cell 11(5):407-20,2007.

    12. Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 RegulatesCytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells. Cell 129(1):111-22, 2007.

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