ZHANG Huafeng




Huafeng Zhang (张华凤), Professor, School of Life Sciences, USTC,
443 Huangshan Road, Hefei 230027, China
Tel: 86-551-63607131(O) and 86-551-3607012(lab)
Homepage: http://staff.ustc.edu.cn/~hzhang22/index.html
Personal Profile
Dr. Huafeng Zhang obtained Ph. D degree from University of Tokyo in Japan in 2004. She went on for her postdoctoral study in National Cancer Institute of NIH from 2004 to 2005, studying protein dynamics. From 2005 to 2010, she worked in the laboratory of Dr. Gregg Semenza in Johns Hopkins University to study hypoxia and cancer development. Her major achievements include multiple highly-cited papers in the field of cancer research. She has published more than 40 research papers that are cited more than 3000 times by peer scientists. She was selected into the CAS Hundred Talents Program and Thousand Youth Talents Program in 2011 and has since been a professor in School of Life Science USTC. She is also joint-appointed as a faculty member at Division of Bio-X Interdisciplinary Sciences, Hefei National Laboratory for Physical Science at Microscale.
Research Interests
1.Tumor microenvironment and metabolism
2.Tumor microenvironment and metastasis
3.Epigenetic changes in tumor development
4.Screening and developing new anti-cancer molecules for cancer therapy
Selected Publications 
 1). Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H*.  HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports 2014 Sep 25;8(6):1930-42.

2). Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Wang Y, Gao P*, Tang H*, Zhang H*  cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation  Conditions. Cell Research 2015 Apr;25(4):429-44

3). Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P*, Zhang H*. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications. 2014 Oct 10;5:5212.

4). Yuan Y, Wang L, Du W, Ding Z, Zhang J, Han T, An L, Zhang H*, Liang G*. Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9700-4

5). Li Z, Zhang H*.  Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression. Cell Mol Life Sci. 2015 Oct 23. [Epub ahead of print] PMID:26499846

6). Huang D, Li C, Zhang H*. Hypoxia and cancer cell metabolism. Acta Biochim Biophys Sin. 2014 Mar;46(3):214-9.

7). Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL*. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31(14), pp1557-70, 2012.

8). Yoshida T#, Zhang H# Shen J, Semenza GL, Campochiaro P.Digoxin Inhibits Retinal Ischemia-induced HIF-1a Expression and Ocular Neovascularization FASEB J. 24(6):1759-67,2010 (#Equal Contributors).

9). Zhang H, Qian DZ, Tan Y, Lee K,Gao P, Ren YR,Rey S, Hammers H, Chang D,1 Pili R, Dang CV, Liu JO and Semenza GL. Digoxin and Other Cardiac Glycosides Inhibit HIF-1a Synthesis and Block Tumor Growth. PNAS 105(50):19579-86,2008.

10). Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem.283(16):10892-903,2008.

11). Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Dang CV., Semenza GL. HIF-1 represses mitochondrial mass and respiration in VHL-null renal cell carcinoma. Cancer Cell 11(5):407-20,2007.

12). Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL.HIF-1 RegulatesCytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells. Cell. 129(1):111-22,2007.