CANG Chunlei




Chunlei Cang
School of Life Sciences
University of Science & Technology of China
Hefei, China
Tel: (+86) 18655123362

Personal profile
2015 – Present:  Professor, School of Life Sciences, University of Science & Technology of China, China
2009 – 2014: Postdoc, Department of Biology, University of Pennsylvania, US
2003 – 2009: Ph.D., Institute of Neurobiology, Fudan University, China
1999 – 2003: B.Sc., School of Life Sciences, Fudan University, China

Research interests
Properties, functions and modulation of intracellular ion channels, especially the ones exist on membrane of lysosome and endosome.

1.Cang, C., Aranda, K., Seo, YJ., Gasnier, B., Ren, D. (2015) TMEM175 is an Organelle K(+) Channel Regulating Lysosomal Function. Cell 162(5): 1101-12. Doi:10.1016/j.cell.2015.08.002
2.Cang, C., Zhou, Y., Navarro, B., Aranda, K., Shi, L., Battaglia-Hsu, S., Nissim, I., Clapham, D. and Ren, D. (2013) mTOR Regulates Lysosomal ATP-sensitive Two-Pore Na+ Channels to Adapt to Metabolic State. Cell 152: 778-790
3.Cang, C.*, Aranda, K., Ren, D.*. A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability. Nature communications 5: 5015 (*co-corresponding authors)
4.Cang, C.*, Bekele, B., Ren, D.*. (2014) The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nature Chemical Biology 10: 463-469 (*co-corresponding authors)
5.Cang CL, Zhang H, Zhang YQ, Zhao ZQ (2009) PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Mol Pain 5:33
6.Zhang H., Cang CL, Kawasaki Y, Liang LL, Zhang YQ, Ji RR, Zhao ZQ (2007) Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKC: a novel pathway for heat hyperalgesia. J Neurosci 27: 12067-12077
7.Xu SY, Cang CL, Liu XF, Peng YQ, Ye YZ, Zhao ZQ, Guo AK (2006) Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene. Genes Brain Behav 5: 602–613