Dong LongPh.D.

Professor, School of Life Sciences

University of Science and Technology of China

443 Huangshan Street

Hefei, Anhui 230027

P. R. China

Email: dlong[at]ustc.edu.cn


Personal Profile:

B.Sc.  (2005)  Wuhan University, Wuhan, Hubei,  China 

Ph.D.  (2010)  National University of Singapore,  Singapore

2010 - 2012, Postdoctoral Fellow, Florida State University/National High Magnetic Field Laboratory, Tallahassee, Florida, United States

2012 - 2015, Postdoctoral Fellow, University of Toronto, Toronto, ON, Canada

2015 - present , Professor, University of Science and Technology of China, Hefei, China


Research Interest

•  Investigation of the structures and dynamical properties of functionally important proteins and other macromolecules using NMR spectroscopy;

•  Computational modeling/simulation of the structure and dynamics of macromolecular systems;

•  Development of NMR and computational methodology for structural and dynamics studies of biomacromolecules.


Selected Publications:

1. H. Wang, S. Wang, C. Li, H. Li, Y. Mao, W. Liu, C. Xu*, D. Long* (2017) Probing transient release of membrane-sequestered tyrosine-based signaling motif by solution NMR spectroscopy. J. Phys. Chem. Lett. 8:3765-3769

2. Y. Mao, H. Yao, H. Wang, P. Cheng, D. Long* (2016) Microsecond timescale dynamics of GDP-bound Ras underlies the formation of novel inhibitor-binding pockets. Angew. Chem. Int. Ed. 55:15629-15632

3. D. Long,* F. Delaglio, A. Sekhar, L. E. Kay* (2015) Probing invisible, excited protein states by non-uniformly sampled pseudo-4D CEST spectroscopy. Angew. Chem. Int. Ed. 54:10507-10511

4. D. Long, A. Sekhar, L. E. Kay (2014) Triple resonance-based 13Cα and 13Cβ CEST experiments for studies of ms timescale dynamics in proteins. J. Biomol. NMR 60:203-208

5. D. Long, G. Bouvignies, L. E. Kay (2014) Measuring hydrogen exchange rates in invisible protein excited states. Proc. Natl. Acad. Sci. U.S.A. 111:8820-8825 (Recommended by Faculty of 1000)

6. D. Long, C. B. Marshall, G. Bouvignies, M. T. Mazhab-Jafari, M. J. Smith, M. Ikura, L. E. Kay. (2013) A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues. Angew. Chem. Int. Ed. 52:10771-10774 (Recommended by Faculty of 1000)

7. H. Sun, D. Long, R. Brüschweiler, V. Tugarinov. (2013) Carbon relaxation in 13Cα-Hα and 13Cα-Dα spin pairs as a probe of backbone dynamics in proteins. J. Phys. Chem. B 117:1308-1320

8. D. Long, R. Brüschweiler. (2013) Directional selection precedes conformational selection in ubiquitin-UIM binding. Angew. Chem. Int. Ed. 52: 3709-3711

9. D. Long, R. Brüschweiler. (2012) Structural and entropic allosteric signal transduction strength via correlated motions. J. Phys. Chem. Lett. 3:1722-1726

10. D. Long, R. Brüschweiler. (2011) Atomistic kinetic model for population shift and allostery in biomolecules. J. Am. Chem. Soc. 133:18999-19005

11. D. Long, D.W. Li, K. Walter, C. Griesinger, R. Brüschweiler. (2011) Toward a predictive understanding of slow methyl group dynamics in proteins. Biophys. J. 101:910-915

12. D. Long, R. Brüschweiler. (2011) In silico elucidation of the recognition dynamics of ubiquitin. PLoS Comput. Biol. 7: e1002035