LI Xu

2015-07-03Source:中科大生命科学院英文站
 

LI Xu 

Ph. D., Associate Professor of School of Life Sciences, USTC

Education Experiences

1997.09-2001.07: Bachelor of Biology Science

University of Science and Technology of China,Hefei

2001.09-2007.07: Ph. D. of Structural Biology

University of Science and Technology of China,Hefei

Research Interests

1. The structural mechanism and biological function of protein-nucleic acid complex interactions

2. The Structural basis for the pathogenesis of pathogenic bacteria

3. The discovery, improvements and industrial applications of the novel enzymes

Research Projects

National Basic Research Program of China (973): 2012CB917202 (2012.1-2016.8); 2009CB825502 (2009.01-2013.12)

National Natural Science Foundation: 31270014 (2013.01-2016.12) ;30900224 (2010.01-2012.12)

Representative Publications

1. Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M., and Li, X. (2014) Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Nucleic Acids Res 42, 9470-9483. (Corresponding Authors)

2. Shao, Z., Yan, W., Peng, J., Zuo, X., Zou, Y., Li, F., Gong, D., Ma, R., Wu, J., Shi, Y., Zhang, Z., Teng, M., Li, X., and Gong, Q. (2014) Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate, Nucleic Acids Res 42, 509-525. (Corresponding Authors)

3. Liu, H., Wang, H., Teng, M., and Li, X. (2014) The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway, ActaCrystallogr D BiolCrystallogr 70, 501-513. (Corresponding Authors)

4. Zhang, W., Zeng, F., Liu, Y., Zhao, Y., Lv, H., Niu, L., Teng, M., and Li, X. (2013) Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation, J BiolChem 288, 22636-22649. (Corresponding Authors)

5. Li, X., Tao, Y., Liu, Y., Ruan, J., Qi, S., Niu, L., and Teng, M. (2012) Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage, J BiolChem 287, 20231-20239. (Co-first Authors)

Contact Information

Email: sachem@ustc.edu.cn

Tel: 86 551 63607334; Fax: 86 551 63606314

Web Site:https://www.researchgate.net/profile/Xu_Li4

 

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