CAI Gang
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    CAI Gang

  • Professor of School of Life Science
    University of Science & Technology of China 
    Tel: 86-551-63603802


    Personal Profile
    • 11/2010-now, School of Life Sciences, University of Science and Technology
    • 03/2006–11/2010, Department of Cell Biology, the Scripps Research Institute       
    • 09/2001-03/2006, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences               
    Ph.D. in Microbiology, 2006
    • 09/1997-07/2001, School of Life of Science, Anhui University
    B.S. in Microbiology

    Research Interests
    Cryo electron microscopy (cryo-EM) is a powerful technique to study both the structure and dynamics of macromolecular complexes in their close to native state. I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of eukaryotic transcription and genome stability, aiming at a structural understanding of the molecular mechanism.

    Selected Publications

    1.Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655, doi:10.1038/ncomms11655 (2016)

    2. Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G*. Redefine the Modular Organization of the Core Mediator Complex. Cell Research 24: 796-808, 2014 (Cover story)

    3. Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G*. Structural flexibility and functional interaction of Mediator Cdk8 module. Protein Cell 4, 911-920, 2013 (Cover story)

    4. Cai, G., Chaban, Y.L., Imasaki, T., Kovacs, J.A., Calero, G., Penczek, P.A., Takagi, Y., and Asturias, F.J.* Interaction of the mediator head module with RNA polymerase II. Structure 20, 899-910, 2012
    5. Imasaki, T., Calero, G., Cai, G., Tsai, K.L., Yamada, K., Cardelli, F., Erdjument-Bromage, H., Tempst, P., Berger, I., Kornberg, G.L., Asturias, F.J., Kornberg, R.D., Takagi, Y*. Architecture of the Mediator head module. Nature 475, 240-243, 2011

    6. Cai, G., Imasaki, T., Yamada, K., Cardelli, F., Takagi, Y.*, and Asturias, F.J.* Mediator head module structure and functional interactions. Nature Structural & Molecular Biology 17, 273-279, 2010
    7.Cai, G., Imasaki, T., Takagi, Y. & Asturias, F.J.*Mediator structural conservation and implications for the regulation mechanism. Structure17, 559-67, 2009. (Cover story)

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