SONG Xiaoyuan
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    SONG Xiaoyuan



  • Xiaoyuan Song Ph.D.
    Professor, School of Life Sciences
    University of Science & Technology of China
    443 Huangshan Street, Hefei, Anhui 230027, P.R.China
    Tel: 86-551-63607752
    E-mail:
    songxy5@ustc.edu.cn
    ResearcherID:P-1094-2014
    Education
    1992-1996 Biology, Beijing Normal University, China, B.A.
    1996-1999 Molecular Cell Biology, Beijing Normal University, China, M.S.
    1999-2006Cell, Molecular and Developmental Biology, University of Rochester, USA, Ph.D.
    2006-2012 University of California, at San Diego, CA, USA,Postdoctoral fellow
    2012.12- University of Science & Technology of China, Professor

    Research Interests
    1. Roles of lncRNAs in transcriptional regulation;
    2. Chromatin interaction-based transcriptional regulation of stress response induced by DNA damage;
    3. Epigenetic regulation in brain aging and senescence, focusing on roles of three-dimensional chromatin networksand lncRNAs.

    Honors
    2012 Youth Thousand Talents Program Award
    2010 ASBMB 2010 Graduate/Postdoctoral Travel Award.
    2010 Scholar-in-Training Award Supported by AACR-Aflac, Inc.
    2008-2011Cancer Research Institute/Irvington Institute Postdoctoral Fellowship
    2001 Biology Department Graduate Student Teaching Award, U. of Rochester

    Selected Publications

    1. Luo Z.*, Hu T. *, Jiang H.Wang R.Xu Q., Zhang S.Cao J., Song X.#. Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila. Genome Research. 2020. Mar 12. doi: 10.1101/gr.241687.118. #Corresponding author.

    2. Cheng Q.*, Ouyang X.*, Zhang R.*, Zhu L., Song X.#. Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. RNA Biology. 2020. Jan 30: 1-14. #Corresponding author.

    3. Cao J., Jiang H.*, Zhang R.*, Ghanam AR.*, Xia H., Zhu Y., Yang Z., Song X.#. Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance. Science Bulletin. 2019. 64: 1132-1135. #Corresponding author.

    4. Ghanam AR., Cao J., Ouyang X., and Song X.#. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019. 2818415. eCollection 2019. #Corresponding author.

    5. Wang F.*, Ren D.*, Liang X.*, Ke S., Zhang B., Hu B.#, Song X.#, Wang X.#. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019, 47(12): 6315-6329. #Corresponding author.

    6. Mamun M.Al., Mannoor K., Cao J., Qadri F., Song X.#. SOX2 in cancer stemness: Tumor malignancy and therapeutic potentials. Journal of Molecular Cell Biology. 2018. doi: 10.1093/jmcb/mjy080. #Corresponding author.

    7. Ghanam AR., Xu Q., Ke Sh., Azhar M., Cheng Q., Song X.#. Shining the light on senescence associated lncRNAs. Aging & Disease. 2017, 1; 8(2):149-161. # Corresponding author.

    8. Xu Q., Wang R., Ghanam AR., Yan G., Miao W., Song X. #. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein & Cell. 2016, 7(4):236-49. #Corresponding author.

    9. Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.#. Three-dimensional regulation of transcription. Protein & Cell. 2015, 6(4):241-53. # Corresponding author.

    10. Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.#. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29.

    11. Song X.*, Wang X.*, Arai S. and Kurokawa R.#. Promoter-associated noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. *Co-first author.

    12. Harismendy O.*, Notani D.*, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG#, and Frazer KA#. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. *Co-first author.  

    13. Wang X.* and Song X.*, Glass CK., and Rosenfeld MG#. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol. 2011 3(1):a003756. *Co-first author. Collected inThe RNA WorldIV.

    14. Wang X., Arai S.*, Song X.*, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.#, Glass CK.#, and Kurokawa R.#. Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription. Nature. 2008, 454(7200):126-30.   

    15. Song, X.*, Gjoneska E.*, Ren Q.*, Taverna SD., Allis C.D., and Gorovsky MA.#. Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. *Co-first author. 

    16. Song X. and Gorovsky MA.#. Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation. Mol Cell Biol. 2007, 27(5):1925-33.

    17. Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.#. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9.

     



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