YAO Xuebiao


Cheung Kong Scholar

Anhui Key Laboratory of Cell Dynamics & Chemical Biology

School of Life Science

University of Science & Technology of China

Tel: 0551-63607141


E-mail: yaoxb@ustc.edu.cn


Personal Profile:

Dr. Xuebiao Yao received his Ph.D. from University of California at Berkeley under Professor John Forte’s supervision in 1995, and pursued a postdoctoral fellowship at the Ludwig Institute for Cancer Research with Professor Don Cleveland before joining the faculty of the University of Wisconsin-Madison as an Assistant Professor in 1998. He was selected as a Chueng Kong Scholar of the Ministry of Education and received an Outstanding Young Scientist Award from Natural Science Foundation of China in 1999. Dr. Yao built the Laboratory of Cellular Dynamics in the University of Science & Technology in 2000 and became the Principal Investigator for the State-sponsored Key Basic Science project titled “Regulatory protein interacting networks underlying cell division” in 2002. Dr. Yao’s research interest is centered on the molecular mechanisms underlying cellular plasticity and dynamics. Using kinetochore as a model system, his research team has identified several important kinetochore interacting networks and pathways essential for accurate chromosome segregation. Among many affiliated responsibilities, Dr. Yao serves as an Associate Editor of Journal of Molecular & Cell Biology, and board members of Journal of Biological Chemistry and Cell Research.

Research Interests:

Cellular Dynamics and Chemical Biology of cell division and migration in health and diseases

Selected Publications:

Xia P, Liu, Wu B, Zhang S, Song X, Yao PY, Lippincott-Schwartz J, & Yao X. (2014). Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking. Mol Biol.Cell 25, 4166-74.

Yu H, Zhou J, Takahashi H, Yao W, Suzuki Y, Yuan X, Yoshimura SH, Zhang Y, Liu Y, Emmett N, Bond V, Wang D, Ding X, Takeyasu K, & Yao X. (2014) Spatial control of proton pump H,K-ATPase docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 interaction. J Biol. Chem. 289, 33333-42

Wang J, Liu X, Dou Z, Chen L, Jiang H, Fu C, Fu G, Liu D, Zhang J, Zhu T, Fang J, Zang J, Cheng J, Teng M, Ding X, & Yao X. (2014) Mitotic regulator Mis18β interacts with and specifies the centromeric assembly of molecular chaperone HJURP. J Biol Chem. 289, 8326-8336.

Liu X, Song Z, Huo Y, Zhang J, Zhu T, Wang J, Zhao X, Aikhionbare F, Zhang J, Duan H, Wu J, Dou Z, Shi Y, & Yao X. (2014). HP1 interacts with borealin and specifies the centromere localization of chromosomal passenger complex. J Biol Chem. 289, 20638-20649.

Chu L, Huo Y, Liu X, Yao P, Thomas K, Jiang H, Zhu T, Zhang G, Chaudhry M, Adams G, Thompson W, Dou Z, Jin C, He P, & Yao X. (2014) Spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division. J Biol Chem. 289, 26249-62.

Zhao X, Wang D, Liu X, Liu L, Song Z, Zhu T, Adams G, Gao X, Tian R, Huang Y, Chen R, Wang F, Liu D, Yu X, Chen Y, Chen Z, Teng M, Ding X, & Yao X. (2013) Phosphorylation of BAR domain of ACAP4 regulates membrane tubulation. Proc Natl Acad Sci U S A. 110, 11023-8.

Xia P, Wang Z, Liu X, Zhang L, Dou Z, Ding X, & Yao X. (2012). Acetylation-dependent regulation of kinetochore microtubule signaling by PCAF acetyltransferase. Proc. Natl. Acad. Sci. 109, 16564-9.

Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X, & Teng M. (2012). The structure of structure of the FANCM-MHF complex reveals physical features for functional assembly. Nature Commun. 3, 782-791. (co-corresponding author)

Chu L, Zhu T, Liu X, Yu R, Bacanamwo M, Gibbons G, Zou H, Dou Z, Wang D, Ding X, & Yao X. (2012). SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis. J Mol Cell Biol. 4, 331-340.

Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, Liu B, Deng H, Yao H, Su F, Anderson KS, Liu Q, McEwen M, Yao X, & Song E. (2011). CCL18 from tumor associated macrophages promotes breast cancer metastasis via CCR18. Cancer Cell. 19, 541-55. (co-corresponding author; highlighted by Cancer Cell & Nature)

Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Xiang H, Gao F, Yu X, Liao J, Ward T, Xia P, Emenari C. Ding X, Thompson W, Ma K, Zhu J, Aikhionbare F, Dou K, Zhu J, Cheng S, Yao X. (2011). Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Res. 71, 1721-1729.

Ren J, Jiang C, Gao X, Liu Z, Yuan Z, Jin C, Wen L, Zhang Z, Xue Y, & Yao X. (2010). PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation. Mol Cell Proteomics. 9, 623-634.

Ding X, Yan F, Yao P, Yang Z, Wan W, Wang X, Liu J, Gao X, Abrieu A, Zhu T, Zhang J, Dou Z, & Yao X. (2010). Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 20, 1386-9.

Jiang K, Wang J, Liu J, Ward T, Wordeman L, Davidson A, Wang F, & Yao X. (2009). TIP150 interacts with and targets MCAK to the plus-end of microtubules EMBO Rep. 10, 857-65.

Wang S, Guo Z, Xia P, Liu T, Wang J, Li S, Sun L, Lu J, Wen Q, Zhou M, Ma L, Ding X, Wang X, Yao X. (2009). Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death. Cell Res. 19, 1350-1362.

Fu G, Ding X, Yuan K, Aikhionbare F, Yao J, Cai X, Jiang K, & Yao X. (2007). Phosphorylation of Sgo1 by NEK2A is essential for chromosome segregation. Cell Res. 17, 608-618 (Cover story).

Fang Z, Miao Y, Ding X, Deng H, Liu S, Wang F, Zhou R, Watson C, Fu C, Hu Q, Lillard JW Jr, Powell M, Chen Y, Forte JG, & Yao X. (2006). Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein ACAP4. Mol Cell Proteomics 5, 1437-1449 (Cover story).

Yao X, & Forte JG. 2003. Cell biology of acid secretion in the stomach. Ann. Rev. Physiol. 65:103-131.

Yao X, Zheng Y, Sullivan KF, & Cleveland DW. (2000). CENP-E forms a link between attachment of spindle microtubules to kinetochore and the mitotic checkpoint. Nature Cell Biol. 2, 484-491.