SONG Xiaoyuan


Xiaoyuan Song Ph.D.
Professor, School of Life Sciences
University of Science & Technology of China
443 Huangshan Street, Hefei, Anhui 230027, P.R.China
Tel: 86-551-63607752
1992-1996 Biology, Beijing Normal University, China, B.A.
1996-1999 Molecular Cell Biology, Beijing Normal University, China, M.S.
1999-2006Cell, Molecular and Developmental Biology, University of Rochester, USA, Ph.D.
2006-2012 University of California, at San Diego, CA, USA,Postdoctoral fellow
2012.12- University of Science & Technology of China, Professor

Research Interests
1. Roles of lncRNAs in transcriptional regulation;
2. Chromatin interaction-based transcriptional regulation of stress response induced by DNA damage;
3. Epigenetic regulation in brain aging and senescence, focusing on roles of three-dimensional chromatin networksand lncRNAs.

2012 Youth Thousand Talents Program Award
2010 ASBMB 2010 Graduate/Postdoctoral Travel Award.
2010 Scholar-in-Training Award Supported by AACR-Aflac, Inc.
2008-2011Cancer Research Institute/Irvington Institute Postdoctoral Fellowship
2001 Biology Department Graduate Student Teaching Award, U. of Rochester

Selected Publications

1. Luo Z.Hu T.Jiang H.Wang R.Xu Q.Zhang S.Cao J.,and Song X.#. Rearrangement of macronucleus chromosomes correspond to  TAD-like structures of micronucleus chromosomes in Tetrahymena thermophile. Genome Research. 2020. Mar 12. pii: gr.241687.118. #Corresponding author.

2. Cheng Q.Ouyang X.Zhang R.Zhu L., Song X.#. Senescence-associated Genes and Non-Coding RNAs Function in Pancreatic Cancer Progression. RNA Biology. 2020. Jan 30. 1-14. #Corresponding author.

3. Cao J., Jiang H.*, Zhang R*, Ghanam AR*, Xia H., Zhu Y., Yang Z., Song X.#. Epigenomic Profiling Identifies the Role of Nr5a2 and CYP1B1 in Hepatocellular Carcinoma Stemness Maintenance. Science Bulletin. 2019. 64: 1132-1135. #Corresponding author.

4. Ghanam AR, Cao J., Ouyang X. and Song X.#. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019. 2818415. eCollection 2019. #Corresponding author.

5. Wang F.*, Ren D.*, Liang X.*, Ke S., Zhang B., Hu B.#, Song X.#, Wang X.#. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019, 47(12): 6315-6329. #Corresponding author.

6. Mamun M.Al, Mannoor K., Cao J., Qadri F., Song X.#. SOX2 in Cancer Stemness: Tumor Malignancy and Therapeutic Potentials. Journal of Molecular Cell Biology. 2018. doi: 10.1093/jmcb/mjy080. #Corresponding author.

7. Ghanam AR, Xu Q., Ke Sh., Azhar M., Cheng Q., Song X.#. Shining the Light on Senescence Associated LncRNAs. Aging & Disease. 2017, 1; 8(2):149-161. # Corresponding author.

8. Xu Q., Wang R., Ghanam AR., Yan G., Miao W., Song X. #. The key role of CYC2 during meiosis in Tetrahymena thermophile. Protein & Cell. 2016, 7(4):236-49. #Corresponding author.

9. Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.#. Three-dimensional regulation of transcription. Protein & Cell. 2015, 6(4):241-53. # Corresponding author.

10. Song X., Bowen J., Miao W., Liu Y., and Gorovsky, MA#. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29.

11. Song X.*, Wang X.*, Arai S. and Kurokawa R.#. Promoter-Associated Noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. *Co-first author.

12. Harismendy O.*, Notani D.*, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG#, and Frazer KA#. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8.   

13. Wang X.* and Song X.*, Glass CK., and Rosenfeld MG#. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol. 2011 3(1):a003756. doi: 10.1101/cshperspect.a003756. * Co-first author. Collected inThe RNA WorldIV.

14. Wang X., Arai S.*, Song X.*, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG#, Glass CK#, and Kurokawa R#. Induced ncRNAs Allosterically Modify RNA Binding Proteins in cis to Inhibit Transcription. Nature. 2008, 454(7200):126-30.   

15. Song, X.*, Gjoneska E*., Ren Q*., Taverna SD., Allis C.D., and Gorovsky, MA#. Phosphorylation of the SQ H2A.X Motif Is Required for Proper Meiosis and Mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. *Co-first author. 

16. Song, X. and Gorovsky, M.A#. Unphosphorylated H1 Is Enriched in a Specific Region of the Promoter when CDC2 Is Down-Regulated during Starvation. Mol Cell Biol. 2007, 27(5):1925-33.

17. Shang, Y., Song, X., Bowen, J., Corstanje, R., Gao, Y., Gaertig, J., and Gorovsky, MA#. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9.