Professor, Institute of Immunology
School of Life Sciences
University of Science & Technology of China
Address: Huangshan Road 443, Hefei, Anhui, China R.P. 230027
09/1998-06/2002 B.S. University of Science & Technology of China
09/2002-06/2007 Ph.D University of Science & Technology of China
07/2007-02/2011 Postdoc University of Lausanne, Switzerland
03/2011-present Professor University of Science & Technology of China
Our general interest is to understand how pathogen and danger signal trigger innate immunity and inflammation, and includes the following areas:
1.Molecular mechanisms of innate immune recognition and signal transduction: Analysis of the receptors (pattern recognition receptors, PRRs) the involved in innate immune recognition, including identification of new activators and clarification of the signaling transduction pathways. Our particular interest is to understand the signaling networks that control the activation of “inflmmaosme”.
2.Basic biology of inflammation:
Inflammation is a fundamental biological response to harmful stimuli, such as pathogens and danger. We are studying the signaling networks that control the initiation, progression and termination of inflammatory responses. We also have interest to understand the links between inflammation and metabolism disorder, inflammation and cancer.
Selected publications（*co-corresponding author）
1. Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 ;160(1-2):62-73.
2. Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014 ;15(12):1126-33.
3. Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J. RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice. Cell Host Microbe. 2015;17(2):229-42.
4. Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R, Tian Z. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 pii: S0168-8278(14)00956-8.
5. Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z*, Zhou R*. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med. 2013;21;210(11):2465-76.
6. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z*, Tschopp J, Zhou R*. ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013;38(6):1154-63.
7. Zhang Z, Xu X, Ma J, Wu J, Wang Y, Zhou R, Han J. Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses. J Immunol. 2013;190(7):3517-24.
8. Zhou R, Yazdi A, Menu P,Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469(7329):221-5
9. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010;11(2):136-40.
10. Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010;327(5963):296-300.