2003-2007, Department of biology, Harbin Institute of Technology, Bioengineering.
2007-2012, School of Life Sciences, University of Science & Technology of China, Cell Biology.
2012-present, Associate Research Fellow, University of Science & Technology of China, Hefei.
Biological Function of Nanomaterial: investigating the novel effects of rare earth nanomaterials especially upconversion nanoparticles on autophagy and inflammatory effects as well as the clinic application in cancer, neurodegenerative diseases and other diseases.
Bio-inspired Nanomaterial Improvement: developing peptide-based coating material to improve water dispersibility, biocompatibility and targeting properties of upconversion phosphors and other rare earth nanomaterial
Specific functional peptide-mediated nanomedicine：investigating applications of rare earth nanoparticles-surface coating peptide as well as circulation-prolonging peptide in anti-tumor and inflammatory diseases.
1. Zhang YJ, Zheng F, Yang T, Zhou W, Liu Y, Man N, Zhang L, Jin N, Dou Q, Zhang Y, Li Z, Wen LP*. Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nat. Mater. 2012; 11(9):817-26.
2. Miao Y, Xu J, Shen Y, Chen L, Bian Y, Hu Y, Zhou W, Zheng F, Man N, Shen Y, Zhang YJ, Wang M*, Wen LP*. Nanoparticle as signaling protein mimic: robust structural and functional modulation of CaMKII upon specific binding to fullerene C60 nanocrystals. ACS Nano 2014; 8(6):6131-44.
3. Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, Zhang YJ, Zheng F, Wang Y, Li Y, Gu N*, Wen LP*. Inhibition of autophagy enhances the anticancer activity of silver nanoparticles. Autophagy 2014; 10(11):2006-20.
4. Wei PF, Zhang L, Nethi SK, Barui AK, Lin J, Zhang YJ, Xu J, Patra CR*, Wen LP*. Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods. Biomaterials 2014; 35(3):899-907.
5. Chen L, Miao Y, Chen L, Jin P, Zha Y, Chai Y, Zheng F, Zhang YJ, Zhou W, Zhang J, Wen LP, Wang M. The role of elevated autophagy on the synaptic plasticity impairment caused by CdSe/ZnS quantum dots. Biomaterials 2013; 34(38):10172-81;
6. Zhou W, Miao Y, Zhang YJ, Liu L, Lin J, Yang JY, Xie Y, Wen LP. Induction of cyto-protective autophagy by paramontroseite VO2 nanocrystals. Nanotechnology 2013; 24(16):165102
7. Ruan RQ, Wang SS, Wang C, Zhang L, Zhang YJ, Zhou W, Ding WP, Jin PP, Wei PF, Man N, Wen LP*. Transdermal delivery of human epidermal growth factor facilitated by a peptide chaperon. Eur J Med Chem 2013; 62:405-409