SHI Qinghua
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    SHI Qinghua

  • SHI Qinghua

    Professor, Professor in Genetics & Cell Biology, Reproductive Biology
    School of Life Sciences
    University of Science & Technology of China
    Lab website:


    Personal Profile
    B.S. Biology, Nanjing Normal University, Nanjing, China 1981-1985
    M.S. Cell Biology, Kunming Institute of Zoology, Chinese Academy of Sciences, China 1985-1988
    Ph.D. Genetics, Nanjing Normal University, Nanjing, China & GSF-National Research Center for Environment & Health, Munich, Germany 1994-1998

    Research Profile
    Shi Qinghua, professor and Ph.D. supervisor, is selected into Chinese Academy of Sciences (CAS) Hundred Talents Program and winner of National Natural Science Funds for Distinguished Young Scholars.
    1992.10-1993.11 GSF-National Research Center for Environment & Health, Germany, Guest Scientist
    1996.10-1997.12 GSF-National Research Center for Environment & Health, Germany and Nanjing Normal University, China, jointly trained Ph.D. candidate
    1998.11-2001.12 University of Calgary, Canada,Postdoctoral Fellow
    2002.1-2004.12Harvard Medical School, USA, Research Fellow
    2004.12-Hefei National Laboratory for Physical Sciences at Microscale& University of Science &Technology of China, Professor&Principal Investigator
    Selected into CAS Hundred Talents Program in 2005.
    Won the support of National Natural Science Founds for Distinguished Young Scholars in 2007.
    Selected to be Research Chair for the National Major Research Project “Molecular Regulation of Follicular Development” in 2007.
    2011.19-Hefei Institutes of Physical Science, Chinese Academy of Sciences, Professor
    Selected to be Research Chair for the National Major Research Project “Mechanisms of Meiosis” in 2013.

    Research Interests
    1. Cellular and molecular regulation of mammalian meiosis.
    2. Origins and mechanisms of mitotic and meiotic aneuploidy.
    3. Molecular basis and mechanisms of human infertility.

    Selected Publications  (*Corresponding author)
    1. Shi Q, King RW*. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437:1038-1042, 2005.
    2. Chu B, Zhong L, Dou S, Wang J, Li J, Wang M, Shi QH*, Mei Y*, Wu M*. miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor.Journal of Molecular Cell Biology 7(1):12-22, 2015.
    3. Jiang X, Ma T, Zhang Y, Zhang H, Yin S, Zheng W, Wang L, Wang Z, Khan M, Sheikh SW, Bukhari I, Iqbal F, Cooke HJ, Shi Q*. Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice.Biology of Reproduction.pii: biolreprod.114.126334. 2015 Jan 28. 
    4. Wang L, Xu Z, Iqbal F, Zhong L, Zhang Y, Wu C, Zhou G, Jiang H, Bukhari I, Cooke HJ, Shi Q*. Decreased XY recombination and disturbed meiotic prophase I progression in an infertile 48, XYY, +sSMC man.Chromosome Res. 2015 Jan 28.
    5. Wang Z, Yin H, Zhang Y, Feng Y, Yan Z, Jiang X, Bukhari I, Iqbal F, Cooke HJ, Shi Q*. miR-214-mediateddownregulation of RNF8 induces chromosomal instability in ovarian cancer cells.Cell Cycle  13(22):3519-3528, 2014.
    6. Jiang X, Zhang H, Yin S, Zhang Y, Yang W, Zheng W, Wang L, Wang Z, Bukhari I, Cooke HJ, Iqbal F, Shi Q*. Specific deficiency of Plzfparalog, Zbtb20, in Sertoli cells does not affect spermatogenesis and fertility in mice.Scientific Reports 4:7062, 2014.
    7. Jiang XH, Bukhari I, Zheng W, Yin S, Wang Z, Cooke HJ, Shi QH*. Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice.Asian Journal of Andrology 16(4):572-80, 2014. Invited review.
    8. Zhang H, Jiang X, Zhang Y, Xu B, Hua J, Ma T, Zheng W, Sun R, Shen W, Cooke HJ, Hao Q, Qiao J, Shi Q*. microRNA 376a regulates follicle assembly by targeting Pcna in fetal and neonatal mouse ovaries.Reproduction 148(1):43-54, 2014.
    9. Jiang H, Wang L, Cui Y, Xu Z, Guo T, Cheng D, Xu P, Yu W, Shi Q*. Meiotic chromosome behavior in a human male t(8;15) carrier.Journal of Genetics and Genomics 41(3):177-85, 2014.
    10. Ma H, Cooke HJ, Shi Q*. Meiosis: recent progress and new opportunities.Journal of Genetics and Genomics 41(3):83-85, 204. Editorial
    11. Wang J, Qian J, Hu Y, Kong X, Chen H, Shi Q, Jiang L, Wu C, Zou W, Chen Y, Xu J, Fang JY. ArhGAP30 promotes p53 acetylation and function in colorectal cancer.Nature Communications. 5:4735, 2014.
    12. Wang Z, Yin H, Lv L, Feng Y, Chen S, Liang J, Huang Y, Jiang X, Jiang H, Bukhari I, Wu L, Cooke HJ, Shi Q*. Unrepaired DNA damage facilitates elimination of uniparental chromosomes in interspecific hybrid cells.Cell Cycle 13(8):1345-56, 2014.
    13. Yang Q, Hua J, Wang L, Xu B, Zhang H, Ye N, Zhang Z, Yu D, Cooke HJ, Zhang Y, Shi Q*. MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing.PLoS One 8(6):e66809, 2013.
    14. Wu J, Liu Q, Wang X, Zheng J, Wang T, You M, Sheng Sun Z, Shi Q. mirTools 2.0 for non-coding RNA discovery, profiling and functional annotation based on high-throughput sequencing.RNA Biol.10(7)1087-92, 2013. 
    15. Zhang Y, Zhong L, Xu B, Yang Y, Ban R, Zhu J, Cooke HJ, Hao Q, Shi Q.SpermatogenesisOnline 1.0: a resource for spermatogenesis based on manual literature curation and genome-wide data mining.Nucleic Acids Res. 41: D1055-62, 2013.
    16. Lv L, Zhang T, Yi Q, Huang Y, Wang Z, Hou H, Zhang H, Zhang W, Hao Q, Guo Z, Cooke HJ, Shi Q*. Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse.Cell Cycle11(15):2864-2875, 2012.
    17. Zhang Y, Xu B, Yang Y, Ban R, Zhang H, Jiang X, Cooke HJ, Xue Y, Shi Q*. CPSS: a computational platform for the analysis of small RNA deep sequencing data. Bioinformatics 28(14):1925-1927, 2012.
    18. Yang C, Shi X, Huang Y, Zhang Z, Cooke HJ, Wang M, Shi Q*. Rapid proliferation of daughter cells lacking particular chromosomes due to multipolar mitosis promotes clonal evolution in colorectal cancer cells.Cell Cycle 11(14): 11(14):2650-9, 2012.
    19. Hou H, Zhang Y, Huang Y, Yi Q, Lv L, Zhang T, Chen D, Hao Q, Shi Q*. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells.PLoS One 7(4):e35665, 2012.
    20. Huang Y, Jiang L, Yi Q, Lv L, Wang Z, Zhao X, Zhong L, Jiang H, Rasool S, Hao Q, Guo Z, Cooke HJ, Fenech M, Shi Q*. Lagging chromosomes entrapped in micronuclei are not 'lost' by cells. Cell Res 22(5):932-935, 2012.
    21. Pan Z, Yang Q, Ye N, Wang L, Li J, Yu D, Cooke HJ, Shi Q*. Complex relationship between meiotic recombination frequency and autosomal synaptonemal complex length per cell in normal human males. Am J Med Genet A158A(3):581-7, 2012.
    22. Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun Q, Shi Q*. Regulation of Asymmetrical Cytokinesis by cAMP during Meiosis I in Mouse Oocytes. PLoS One 7(1):e29735, 2012.
    23. Yi Q, Zhao X, Huang Y, Ma T, Zhang Y, Hou H, Cooke HJ, Yang DQ, Wu M, Shi Q*. p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells. PLoS One 6(11):e27304, 2011.
    24. Chen Q, Shi X, Rudolph C, Yu Y, Zhang D, Zhao X, Mai S, Wang G, Schlegelberger B, Shi Q*. Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines. Chromosome Res 19(7):857-68, 2011.
    25. Yang Q, Zhang D, Leng M, Yang L, Zhong L, Cooke HJ, Shi Q* .Synapsis and meiotic recombination in male Chinese muntjac (Muntiacus reevesi). PLoS One 6(4):e19255, 2011.
    26. Huang Y, Hou H, Yi Q, Zhang Y, Chen D, Jiang E, Xia Y, Fenech M, Shi Q* . The fate of micronucleated cells post X-irradiation detected by live cell imaging. DNA Repair 10:629-38, 2011.
    27. Zhang Y, Yang Y, Zhang H, Jiang X, Xu B, Xue Y, Cao Y, Zhai Q, Zhai Y, Xu M, Cooke HJ, Shi Q*. Prediction of novel pre-microRNAs with high accuracy through boosting and SVM. Bioinformatics 27(10):1436-7, 2011.
    28. Xu B, Hua J, Zhang Y, Jiang X, Zhang H, Ma T, Zheng W, Sun R, Shen W, Sha J, Cooke HJ, Shi Q*. Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries. PLoS One 6(1):e16046, 2011.
    29. Huang Y, Shi Q*. Micronucleus formation detected by live-cell imaging. Mutagenesis 26(1):133-8, 2011.
    30. Cai X, Li J, Yang Q, Shi Q*. Gamma-irradiation increased meiotic crossovers in mouse spermatocytes.Mutagenesis 26(6):721-7, 2011.
    31. Leng M, Li G, Zhong L, Hou H, Yu D, Shi Q*. Abnormal synapses and recombination in an azoospermic male carrier of a reciprocal translocation t(1;21).FertilSteril 91(4):1293.e17-22, 2009.
    32. Rao X, Zhang Y, Yi Q, Hou H, Xu B, Chu L, Huang Y, Zhang W, Fenech M, Shi Q* . Multiple origins of spontaneously arising micronuclei in HeLa cells: direct evidence from long-term live cell imaging. Mutat Res 646(1-2):41-9, 2008.
    33. Li JH, Leng M, Ma TL, Yu DX, Shi HQ, Shi QH*. Cryopreservation has no effect on meiotic recombination and synapsis in testicular tissues. FertilSteril 91(4Suppl):1404-7, 2009.
    34. Shi Q, Spriggs E, Field LL, Rademaker A, Ko E, Barclay L, Martin RH*. Absence of age effect on meiotic recombination between human X and Y chromosomes. Am J Hum Genet 71(2):254-261, 2002.



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