JIN Tengchuan
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    JIN Tengchuan

  •  

    Tengchuan Jin, Ph.D.

    Tenure-Track Investigator

    Phone: +86-551-63600720

    E-mail: jint@ustc.edu.cn

    Lab Website: Tjlab.ustc.edu.cn

    Mailing Address:

    Biomedical Science Building, Rm 304 Mid-campus, USTC

    Hefei, Anhui 230027 China

    Personal Profile

    Dr. Jin graduated from the University of Science and Technology of China (USTC) in 2003 with a Bachelor’s Degree in Biology and received his Ph.D. degree in Molecular Biochemistry and Biophysics (MBB) from the Illinois Institute of Technology (IIT) in 2008. His Ph.D. advisor is Dr. Yuzhu Zhang. The main topic of his Ph.D. thesis is the structural characterization of TNF family ligand TL1A and food allergens. In 2008, he received the Sigma Xi Award from the Illinois Institute of Technology for Outstanding Accomplishments in Research and Scholarship.

    During 2008-2014, Dr. Jin did his Postdoctoral training with Dr. Tsan Xiaoat the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). Dr. Jin was promoted to a Research Fellow at the end of 2012.His research focused on the molecular mechanisms of innate immune activation by DNA, which has important implications in bacterial and viral infections, as well as autoimmune diseases such as lupus. He studied severalfamilies of pattern recognition receptors including the PYHIN family proteins, RAGE/HMGB1 proteins, and NOD-like receptors (NLRs). Dr. Jin solved the structure of a key cytosolic DNA sensor, AIM2, in complex with DNA, which is the first structure of an inflammasome complex with a ligand (Jin et al. Immunity 2012). Based on the structure, he identified a conserved DNA binding mode of the PYHIN family members AIM2 and IFI16. The results provided mechanistic insights into AIM2 self-inhibition and subsequent inflammasome assembling around dsDNA. In a collaborative effort with Latz group, they found that RAGE (Receptor for Advanced Glycan End-product) was a direct extracellular nucleic acid receptor, as demonstrated by X-ray crystal structure of the RAGE:DNA complex and in vivo data (Sirois and Jin et al. J Exp Med 2013).

    In the beginning of 2015, Dr. Jin joined the School of Life Sciences at the University of Science and Technology of China as a Tenure-Track Investigator and started the Structural Immunology Laboratory.

    Research Interests

    The long-term research goal of the Laboratory of Structural Immunology is to use molecular, biochemical, and immunological methodologies to expand the understanding of infectious as well as autoimmune diseases, and to improve the quality of life for patients. We are particularly interested in the following four major research areas:

    1)Structural biology of the innate immune receptors

    2)Structure and function of inflammasome

    3)Molecular mechanism of microbe-host interactions

    4)Protein engineering and drug discovery

    Selected Publications (#First author, *Corresponding author):

    1.A comprehensive analysis of the allergenicity and IgE epitopes of myosinogen allergens in Scylla paramamosain. Yang Y, Hu MJ, Jin T, Zhang YX, Liu GY, Li YB, Zhang ML, Cao MJ, Su WJ, Liu GM* (2019). Clin Exp Allergy 49(1):108-119.

    2.Duan GF, Ye Y, Xu S, Tao W, Zhao S, Jin T, Nicoll RA, Shi YS*, Sheng N* (2018). Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nat Commun 9(1):4879.

    3.Chen YL, Li WY, Hu JJ, Li Y, Liu GM, Jin T*, Cao MJ* (2019). Nucleus-translocated matrix metalloprotease 1 regulates innate immune response in Pacific abalone (Haliotis discus hannai)
. Fish Shellfish Immunol 84:290-298.

    4.Yang Y, Liu GY, Yang H, Hu MJ, Cao MJ, Su WJ, Jin T*, Liu GM * (2019). Crystal structure determination of Scylla paramamosain arginine kinase, an allergen that may cause cross-reactivity among invertebrates. Food Chem 271:597-605.

    5.Yang RQ, Chen YL, Chen F, Wang H, Zhang Q, Liu GM, Jin T*, Cao MJ* (2018). Purification, Characterization, and Crystal Structure of Parvalbumins, the Major Allergens in Mustelus griseus. J Agric Food Chem 66(30):8150-8159.

    6.Jin T*,, Brefo. E, Fan W, Zeng W, Li Y, Zhang YZ, Palmer M (2018). Crystal structure of the Streptococcus agalactiae CAMP factor provides insights into its membrane-permeabilizing activity. J Biol Chem 293(30):11867-11877.

    7.Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T* (2018). Functional and Structural Characterization of Zebrafish ASC. FEBS J 285(14):2691-2707.

    8.Fang K, Li Y, Yin X, Samad A, Jin T* (2018). High-Level Prokaryotic Expression and Purification of Death Domain Superfamily with MBP Tag. Clin Lab. 64(4):467-475.

    9.Zhou K, Fan X, Li Y, Zhang C, Jin T* (2018). High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr F Struct Biol Commun 74(Pt 4):236-244.

    10.Jin T*, Huang M, Jiang J, Smith P, Xiao TS* (2018). Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction. PLoS One 13(1): e0190547.

    11.Hu JJ, Chen YL, Duan XK, Jin T, Li Y, Zhang LJ, Liu GM, Cao MJ* (2018). Involvement of clip-domain serine protease in the anti-Vibrio immune response of abalone (Haliotis discus hannai)-Molecular cloning, characterization and functional analysis. Fish Shellfish Immunol 72:210-219.

    12.Gong T, Yang Y, Jin T, Jiang W, Zhou R* (2018). Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes. Trends Immunol 39(5):393-406.

    13.Jin T*, Wang C, Zhang CY, Wang Y, Chen YW, Guo F, Howard A, Cao MJ, Fu TJ, McHugh TH, Zhang YZ* (2017) Crystal Structure of Cocosin, A Potential Food Allergen from Coconut 
(Cocos nucifera). J Agric Food Chem 65(34): 7560-7568.

    14.Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R* (2017). Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med 214(11): 3219-3238.

    15.Jin T*, Chuenchor W, Jiang J, Cheng J, Li YJ, Fang K, Huang M, Smith P, Xiao TS* (2017). Design of an expression system to enhance MBP-mediated crystallization. Sci Rep 7:40991-40997.

    16.Balinsky CA, Schmeisser H, Wells AI, Ganesan S, Jin T, Singh K, Zoon KC. IRAV (FLJ11286), an Interferon Stimulated Gene with Antiviral Activity Against Dengue Virus, Interacts with MOV10 (2016). J Virol. pii: e01606-16.

    17.Cao X#, Li YJ#*, Jin X, Li YL, Guo F, Jin T* (2017). Molecular Mechanism of Divalent-Metal-Induced Activation of NS3 Helicase and Insights into Zika Virus Inhibitor Design. Nucleic Acids Res 44(21): 10505-10514.

    18.Zhang C, Feng T, Cheng J, Li YJ, Yin X, Zeng W, Jin X, Li YL, Guo F and Jin T* (2017). Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design. Biochem Biophs Res Commun492(4):624-630.

    19.Li YJ, Li YL, Cao X, Jin X, and Jin T* (2017). Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways. Cell Mol Immunol 14(1):80-89.

      

    For complete list of publications, please see Dr. Tengchuan Jin’s PubMed link and Google Scholar page.

    We welcome students with backgrounds in Physics, Chemistry, Computer Science, Biology or Medicine join our group. We do not discriminate race, sex, age, and believe.


     

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