JIN Tengchuan, Ph.D.
Lab Website: Tjlab.ustc.edu.cn
Biomedical Science Building, Rm 304
Hefei, Anhui 230027 People's Republic of China
Dr. Jin graduated from the University of Science and Technology of China (USTC) in 2003 with a Bachelor’s Degree in Biology and received his Ph.D. degree in Molecular Biochemistry and Biophysics (MBB) from the Illinois Institute of Technology (IIT) in 2008. His Ph.D. advisor is Dr. Yuzhu Zhang. The main topic of his Ph.D. thesis is the structural characterization of TNF family ligand TL1A and food allergens. In 2008, he received the Sigma Xi Award from the Illinois Institute of Technology for Outstanding Accomplishments in Research and Scholarship.
During 2008-2014, Dr. Jin did his Postdoctoral training with Dr. Tsan Xiaoat the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). Dr. Jin was promoted to a Research Fellow at the end of 2012.His research focused on the molecular mechanisms of innate immune activation by DNA, which has important implications in bacterial and viral infections, as well as autoimmune diseases such as lupus. He studied severalfamilies of pattern recognition receptors including the PYHIN family proteins, RAGE/HMGB1 proteins, and NOD-like receptors (NLRs). Dr. Jin solved the structure of a key cytosolic DNA sensor, AIM2, in complex with DNA, which is the first structure of an inflammasome complex with a ligand (Jin et al. Immunity 2012). Based on the structure, he identified a conserved DNA binding mode of the PYHIN family members AIM2 and IFI16. The results provided mechanistic insights into AIM2 self-inhibition and subsequent inflammasome assembling around dsDNA. In a collaborative effort with Latz group, they found that RAGE (Receptor for Advanced Glycan End-product) was a direct extracellular nucleic acid receptor, as demonstrated by X-ray crystal structure of the RAGE:DNA complex and in vivo data (Sirois and Jin et al. J Exp Med 2013).
In the beginning of 2015, Dr. Jin joined the School of Life Sciences at the University of Science and Technology of China as a Tenure-Track Investigator, and was elected to the “Hundred Talents Program” of the Chinese Academy of Science.
The long-term research goal of the Laboratory of Structural Immunology is to use molecular, biochemical, and immunological methodologies to expand the understanding of infectious as well as autoimmune diseases, and to improve the quality of life for patients. We are particularly interested in the following four major research areas:
1) Structural biology of the innate immune receptors
2) Structure and function of inflammasome
3) Molecular mechanism of microbe-host interactions
4) Protein engineering and drug discovery
(#First author, *Corresponding author):
1. Jin T*, Chuenchor W, Jiang J, Cheng J, Li YJ, Fang K, Huang M, Smith P, Xiao TS* (2017). Design of an expression system to enhance MBP-mediated crystallization. Sci Rep 7:40991-40997. doi:10.1038/srep40991
2. Balinsky CA, Schmeisser H, Wells AI, Ganesan S, Jin T, Singh K, Zoon KC. IRAV (FLJ11286), an Interferon Stimulated Gene with Antiviral Activity Against Dengue Virus, Interacts with MOV10 (2016). J Virol. pii: JVI.01606-16.
3. Cao X#, Li YJ#*, Jin X, Li YL, Guo F, Jin T* (2016). Molecular Mechanism of Divalent-Metal-Induced Activation of NS3 Helicase and Insights into Zika Virus Inhibitor Design. Nucleic Acids Res 44(21):10505-10514. doi: 10.1093/nar/gkw941
4. Zhang C, Feng T, Cheng J, Li YJ, Yin X, Zeng W, Jin X, Li YL, Guo F and Jin T* (2016). Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design. Biochem Biophs Res Commun pii: S0006-291X(16)31963-5.doi: 10.1016/j.bbrc.2016.11.098
5. Li YJ, Li YL, Cao X, Jin X, and Jin T* (2017). Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways.Cell Mol Immunol. doi:10.1038/cmi.2016.50
6. Zhao YJ, Cai QF,Jin T, Zhang LJ, Fei DX, Liu GM and Cao MJ. (2017). Effect of Maillard reaction on the structural and immunological properties of recombinant silver carp parvalbumin. LWT Food Sci. and Technol 75:25-33.
7. Bertheloot D, Naumovski AL, Langhoff P, Horvath GL,Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E* (2016). RAGE Enhances TLR Responses through Binding and Internalization of RNA. J Immunol 15;197(10):4118-4126.
8. Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T,Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M. (2015). Sequencespecific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol 16(10):1025-33.
9.Jin T* and Xiao TS* (2014). Activation and assembly of the inflammasomes through conserved protein domain families. Apoptosis 20(2): 151-6 (review).
10.Jin T*, Wang Y, Chen YW, Albillos SM, Kothary MH, Fu TJ, Tankersley B, McHugh TH, Zhang YZ* (2014). Isolation and characterization of Korean pine (Pinus koraiensis) convicilin.Plant Physiol Biochem 80: 97-104.
11.Chuenchor W#, Jin T#, Ravilious G, Xiao TS* (2014). Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization.Curr Opin Immunol 26:14-20 (review).
For complete list of publications, please see Dr. Tengchuan Jin’s PubMed link and Google Scholar page.
We welcome students with backgrounds in Physics, Chemistry, Computer Science, Biology or Medicine join our group. We do not discriminate race, sex, age, and believe.