BI Guoqiang


Xinchuang Professor and Changjiang Scholar

School of Life Sciences University of Science and Technology of China

Tel: 86-551-63602466




Personal Profile

B.S. Physics Beijing University, Beijing, China, 1985-1989

M.S. Physics New York University, NY, 1990-1991

Ph.D. Biophysics University of California at Berkeley, CA, 1991-1996

Research Interests

We are interested in understanding the neurobiological basis of brain cognitive functions, especially those related to learning and memory. Using a combination of biophysical, molecular and theoretical approaches, research in our laboratory aims at identifying computational rules and underlying mechanisms of neural plasticity as well as their functional relevance from cellular to systems levels.

Selected Publications

1.Bi, G.-Q. and Poo, M.-m. (1998) Synaptic modifications in cultured hippocampal neurons: Dependence on spike timing, synaptic strength, and postsynaptic cell type. J Neurosci 18:10464-10472

2.Bi, G.-Q. and Poo, M.-m. (1999) Distributed synaptic modification in neural networks induced by patterned stimulation. Nature 401:792-796

3.van Rossum, M.C., Bi, G.-Q. and Turrigiano, G.G. (2000) Stable hebbian learning from spike timing-dependent plasticity. J Neurosci 20:8812-8821

4.Bi, G.-Q. and Poo, M.-M. (2001) Synaptic modifications by correlated activity: Hebb's postulate revisited. Ann Rev Neurosci 24:139-166

5.Wang, H.-X., Gerkin, R.C., Nauen, D.W. and Bi, G.-Q. (2005) Coactivation and timing-dependent integration of synaptic potentiation and depression. Nat Neurosci 8:187-193

6.Bi, G.-Q. and Rubin, J.E. (2005) Timing in synaptic plasticity: from detection to integration. Trends Neurosci 28:222-228

7.Lau, P.-M. and Bi, G.-Q. (2005) Synaptic mechanisms of persistent reverberatory activity in neuronal networks. Proc Natl Acad Sci U S A 102:10333-10338

8.Gerkin RC, Lau P.-M., Nauen DW, Wang YT, Bi G.-Q. (2007) Modular Competition Driven by NMDA Receptor Subtypes in Spike-Timing-Dependent Plasticity.  J Neurophysiol 97:2851-2862

9.Zhang JC, Lau P-M, Bi G-Q. (2009) Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses.Proc Natl Acad Sci U S A. 106:13028-33

10.Froemke RC, Debanne D and Bi G-Q (2010) Temporal modulation of spike-timing-dependent plasticity. Front. Syn. Neurosci. 2:19. doi: 10.3389/fnsyn.2010.00019