WU Qingfa
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    WU Qingfa

  • Professor and Ph.D.of Systems Biology School of Life Sciences

    University of Science & Technology of China

    Hefei, Anhui 230027, P.R. China

    Tel: 0551-63607631

    E-mail: wuqf@ustc.edu.cn

    Homepage:http://staff.ustc.edu.cn/~wuqf/
    Education & Working Experience:

    Postdoctoral Fellow /Assistant Specialist, University of California-Riverside, CA, 2006-2010

    Research Associate, Northwestern University, IL, 2004-2006

    Visiting Scholar, Copenhagen University, Denmark, 2001-2002

    Ph.D., Institute of Genetics & Developmental Biology, Chinese Academy of Sciences, 1999-2003

    Research Interests:

    Systems biology of virus-host interaction:  RNA silencing provides protection against virus infection in Drosophila as has been established in plants, but the antiviral mechanism in Drosophila is still very limited. My laboratory concentrates on some fundamental questions in the field: how fruit flies perceive and respond to viruses, and how viruses counter-respond to host defense responses. We are using genomics, computational and molecular approaches to study the dynamic changes of endogenous small RNAs and message RNAs that occur in response to virus challenge.

    Exploiting the functional diversity of non-coding RNAs (ncRNAs):  We are using combined genomic, bioinformatic and high throughput platform technologies to catalogue ncRNAs associated with different chromatin remodeling complexes, dissect the mechanistic roles of ncRNAs in mammalian development. In parallel, both in-house and public gene expression data sets are using to profile gene expression of ES cells and differentiated cells, in order to find lead compounds for the maintenance of ES cell pluripotency and directed differentiation.

    Selected Publications:

    1.Wu Q, Wang X, Ding SW. Viral suppressor of RNA-based viral immunity: Host targets. Cell Host & Microbe. 2010, 8:12-15.

    2.Wu Q, Luo Y, Lu R, Lau N, Lai EC, Li WX, Ding SW. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci USA. 2010, 107(4):1606-1611.

    3.Wang X, Wu Q, Ito T, Cillo F, Li W, Chen X, Yu J, Ding S. RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana. Proc Natl Acad Sci  USA. 2010, 107:484-489.

    4.Kim YC, Wu Q, Chen J, Xuan Z, Jung YC, Zhang MQ, Rowley JD, Wang SM. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc Natl Acad Sci USA. 2009, 106:8278-8283. (Co-first author)

    5.Aliyari R, Wu Q, Li HW, Wang XH, Green L, Han C, Li WX, Ding SW. Mechanism of induction and suppression of antiviral immunity directed by small RNA in Drosophila. Cell Host & Microbe. 2008, 4: 387-397. (Co-first author)

    6.Lu J, Shen Y, Wu Q, Kumar S, He B, Carthew R W, Wang SM, Wu CI. The birth and death of microRNA genes in Drosophila. Nature Genetics. 2008, 40: 351-355.

    7.Wu Q., Kim YC, Lu J, Xuan ZY, Chen J, Zheng YL,Zhou T, Zhang MQ, Wu CI, Wang SM. Poly A- Transcripts Expressed in HeLa Cells. PLos One. 2008, e2803.

    8.Wang J, Zhang M, Wu Q, Huang W, Shen Y, Yu J, Qiang B, Chen Z, Yang H. “Beijing Region” (3pter-D3S3397) of the Human Genome: Complete sequence and analysis. Science in China Series C-Life Sciences. 2005, 48(4): 311-329. (Co-first author)

    9.Wu Q, Niebuhr E, Yang H, Hansen L. Determinating the critical region for cat-like cry of Cri-du-chat and analysis of candidate gene with real-time PCR. Eur J Hum Genet. 2005, 13: 475-485. 

    10.International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature. 2001, 409: 860-921.

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