School of Life Sciences
University of Science and Technology of China
Dr. Sun graduated from the Inner Mongolia University with a B.S. degree in Chemistry in 1990, and the Dalian Institute of Chemical Physics, Chinese Academy of Sciences with an M. S. degree in Physical Chemistry in 1997. In 2002, Dr. Sun obtained his Ph. D. degree in Chemistry from the Division of Chemistry and Chemical Engineering at the California Institute of Technology, where he was supervised by Dr. Frances Arnold. Subsequently, he moved to the University of California at Berkeley/Lawrence Berkeley National Laboratory where he was supervised by Dr. Jay Keasling as a Postdoctoral Researcher. In 2004, Dr. Sun joined the faculty in the Department of Chemical Engineering at the University of Massachusetts Amherst as an Assistant Professor. Dr. Sun moved his lab to the School of Life Sciences at the University of Science and Technology of China in 2011. Dr. Sun won a prestigious United State National Science Foundation CAREER Award in 2008.
Research in the Sun Lab is focused on protein engineering, metabolic engineering and synthetic biology. Using directed evolution, we are interested in engineering industrial enzymes for efficient biotransformation by improving their catalytic activity, stereoselectivity, enatioselectivity, and thermostability. We are also interested in engineering therapeutic enzymes for improved therapeutic efficacy. By engineering metabolic pathways of natural products, we are interested in exploring the pathway and product diversity. In addition, we also develop efficient methods for manufacturing medicinally important natural products, in particular those of the microbial origin. By designing and constructing artificial genetic circuits, we are interested in elucidating the design principles of genetic networks. Development of functional genetic parts with a wide range of dynamic outputs is also of special interest to us.
1.Chen, K., Xu, Y., Miranda, O. R., Dubin, P. L., Rotello, V., Sun, L., Guo, X. Electrostatic Selectivity in Protein-nanoparticle Interactions, Biomacromolecules, 12, 2552-2561, 2011.
2.Xu, Y., Mazzawi, M, Chen, K., Sun, L. and Dubin, P. L. Protein Purification by Polyelectrolyte Coacervation: Influence of Protein Charge Anisotropy on Selectivity, Biomacromolecules, 12, 1512-1522, 2011.
3.Sayut, D. J. and Sun, L. Creating Designer Laccase, Chemistry & Biology, 17, 918-920, 2010.
4.Sayut, D. J. and Sun, L. Slow Activator Degradation Reduces the Robustness of a Coupled Feedback Loop Oscillator, Molecular BioSystems, 6, 1469–1474, 2010.
5.Kambam, P. K. R., Eriksen, D., Lajoie, J., Sayut, D. J. and Sun, L. Altering the Substrate Specificity of RhlI by Directed Evolution, ChemBioChem, 10, 553-558, 2009.
6.Sayut, D. J., Niu, Y. and Sun, L. Construction and Enhancement of a Minimal Genetic AND Gate, Applied and Environmental Microbiology, 75, 637-642, 2009.
7.Kambam, P., Sayut, D. J., Niu, Y., Eriksen, D. T., and Sun, L. Directed Evolution of LuxI for Enhanced OHHL Production, Biotechnology and Bioengineering, 101, 263-272, 2008.
8.Kambam, P., Henson, M. A., and Sun, L. Design and Mathematical Modeling of a Synthetic Symbiotic Ecosystem, IET Systems Biology, 2, 33-38, 2008. (The 16th most downloaded paper for the Journal in 2008.)
9. Sayut, D. J., Kambam, P., and Sun, L. Engineering and Applications of Genetic Circuits, Molecular BioSystems, 3, 835-840, 2007 (Invited Review).
10.Sayut, D. J., Yan, N., and Sun, L. Construction and Engineering of Positive Feedback Loops, ACS Chemical Biology, 1, 692-696, 2006 (Highlighted by ACS Chemical Biology).