Zhiyong ZHANG
Professor
School of Life Sciences
University of Science & Technology of China 
 
Tel: 86-551-63600854
e-mail: zzyzhang@ustc.edu.cn
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Personal Profile
Education
09/1998 – 07/2003, School of Life Sciences, University of Science and Technology of China Ph.D. in Biochemistry and Molecular Biology

09/1994 – 07/1998, Department of Biology, University of Science and Technology of China B.S. in Molecular and Cell Biology

Professional Experience
06/2010 – present, Professor, School of Life Sciences, University of Science and Technology of China

04/2010 – 12/2010, Postdoctoral Scholar, Department of Chemistry, University of Chicago

12/2006 - 03/2010, Postdoctoral Fellow, Department of Chemistry, University of Utah

12/2003 - 12/2006, Postdoctoral Fellow, School of Health Information Sciences, University of Texas Health Science Center at Houston

Research Interests
1. Computational tools for multi-scale modeling of large biomolecules, such as sampling techniques in molecular dynamics simulations and coarse-grained methods

2. Multi-scale modeling to investigate functional dynamics of biomolecules by integrating structural data from various experiments including NMR, cryo-electron microscopy (cryo-EM), and small-angle X-ray scattering (SAXS)

Selected Publications (corresponding author)

11. Jun Dong#, Yonghui Zhang#, Zhiyong Zhang*. pH Dependence of Ligand-Induced Human Epidermal Growth Factor Receptor Activation Investigated by Molecular Dynamics Simulations. Journal of Molecular Modeling 2016: (22): 131

10. Shenglong Ling, Wei Wang, Lu Yu, Junhui Peng, Xiaoying Cai, Ying Xiong, Zahra Hayati, Longhua Zhang, Zhiyong Zhang*, Likai Song*, Changlin Tian*. Structure of an E. Coli integral membrane sulfurtransferase and its structural transition upon SCN-binding defined by EPR-based hybrid method. Scientific Reports 2016 (6): 20025

9. Yonghui Zhang, Junhui Peng, Zhiyong Zhang*. Structural modeling of proteins by integrating small-angle X-ray scattering data. Chinese Physics B 2015 (24): 126101

8. Junhui Peng, Debiao Zhao, Bin Wen, Zhiyong Zhang*. Determining structural models of biomolecular complexes integrating nuclear magnetic resonance, small-angle X-ray scattering and computational simulations. Chinese Journal of Magnetic Resonance 2015 (32): 181-194

7. Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang*. Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations. Protein & Cell 2015 (6): 619-623

6. Zhiyong Zhang*. Systematic methods for defining coarse-grained maps in large biomolecules. Advance in Structural Bioinformatics 2015 (827): 33-48 [book chapter]

5. Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang*. Characterization of protein flexibility using small-angle X-ray scattering and amplified collective motion simulations. Biophysical Journal 2014 (107): 956-964

4. Junhui Peng, Zhiyong Zhang*. Simulating large-scale conformational changes of proteins by accelerating collective motions obtained from principal component analysis. Journal of Chemical Theory and Computation 2014 (10): 3449-3458

3. Debiao Zhao, Xuejuan Wang, Junhui Peng, Chongyuan Wang, Fudong Li, Qianqian Sun, Yibo Zhang, Jiahai Zhang, Gang Cai, Xiaobing Zuo, Jihui Wu, Yunyu Shi, Zhiyong Zhang*, Qingguo Gong*. Structural investigation of the interaction between the tandem SH3 domains of c-Cb1-associated protein and vinculin. Journal of Structural Biology 2014 (187): 194-205

2. Bin Wen, Yunyu Shi, Zhiyong Zhang*. Clustering multi-domain protein structures in the essential dynamics subspace. Journal of Theoretical and Computational Chemistry 2013 (12): 1341008

1. Yonghui Zhang, Zhiyong Zhang*. Progress in structural and computational studies of epidermal growth factor receptor. Biophysics 2013 (1): 11-16

Software: SAXS-ER