WU Mian


Professor, School of Life Sciences,

University of Science & Technology of China


Tel: 86-551-63606264


e-mail: wumian@ustc.edu.cn


Personal Profile

Dr. Wu graduated from Nanjing Normal University in 1981 (BS), and obtained his PhD degree from Columbia University, USA in 1988. He then continuously conducted his postdoctoral research at Harvard University during 1988-1991. Thereafter, he moved to Singapore as an Assistant Professor at School of Biological Sciences of National University of Singapore. Started from 2000, he worked as a full professor at University of Science and Technology of China in Hefei, Anhui. He currently serves on 3 editorial boards including Journal of Molecular and Cell Biology,Acta Biochimica et Biophysica Sinica and Chinese Science bulletin (科学通报).

Research Interests

1.Molecular mechanisms of apoptosis.

2.Mechanism of iPS

3.Regulation of non-coding RNA.

4.p53 and tumor metabolism

Selected Publications

(1)Nan Li, Peng Jiang, Wenjing Du, Zhengsheng Wu, Cong Li, Mengran Qiao,Xiaolu Yang*, and Mian Wu*. Siva1 inhibits epithelial-mesenchymal transition and metastasis of tumor cells.Proc Natl Acad Sci USA.2011(In press)

(2)Peng Jiang, Wenjing Du, Xingwu Wang, Anthony Mancuso, Xiang Gao, Mian Wu* and Xiaolu Yang*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology . 2011 Mar, 13(3):310–316

(3)Guoxing Wang, Xiang Gao, Yun Huang, Zhan Yao, Qinghua Shi and Mian Wu*. NPM/B23 inhibits Eg5-mediated microtubules depolymerization via inactivating its ATPase activity. J Biol Chem. 2010 Jun 18;285(25):19060-7.

(4)Zhan Yao, Shanshan Duan, Dezhi Hou, Wenyu Wang, Guoxing Wang, Yajing Liu, Longping Wen and Mian Wu* B23 acts as a nucleolar stress sensor and promotes cell survival via its dynamic interaction with hnRNPU and hnRNPA1. Oncogene, 2010 Mar 25;29(12):1821-34.

(5)Lin Miao, Zhiyin Song, Lei Jin, Y M Zhu, LP Wen and Mian Wu*. ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation. Oncogene, 2010 Feb 4;29(5):711-22.

(6) Wenjing Du, Peng Jiang, Nan Li , Yide Mei, Xingwu Wang, Longping Wen, Xiaolu Yang* and Mian Wu*. Suppression of p53 activity by Siva1 Cell Death & Differ 2009 Nov;16 6(11):1493-1504. (Featured article)

(7)Shanshan Duan, Zhan Yao, Youming Zhu, Guoxing Wang, Dezhi Hou, Longping Wen and Mian Wu* The Pirh2-Keratin 8/18 interaction modulates the cellular distribution ofmitochondria and UV-induced apoptosis.Cell Death & Differ,2009 Jun;16(6):826-37

(8) Shanshan Duan, Zhan Yao,Dezhi Hou, Zhengsheng Wu, Wei-guo Zhu and Mian Wu*Phosphorylation of Pirh2 by Calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J, 2007 Jul 11;26(13):3062-74.

(9)Zhan Yao, Shanshan Duan, Dezhi Hou, Klaus Heese and Mian Wu*.Death effector domain DEDa, a self-cleaved product of Caspase-8/Mch5,translocates to the nucleus by binding to ERK1/2 and up-regulates procaspase-8 expression via a p53-dependent mechanism. EMBO J, 2007 Feb 21;26(4):1068-80

(10)Jiang P, Du W, Heese K, Wu M*.The Bad Guy Cooperates with Good Cop p53: Bad Is Transcriptionally Up-Regulated by p53 and Forms a Bad/p53 Complex at the Mitochondria To Induce Apoptosis. Mol Cell Biol. 2006 Dec;26 (23):9071-9082