University of Science & Technology of China
September 1989-July 1994, Bachelor of Medicine, Xuzhou Medical College;
September 1994-July 1997, Master of Medical Science, Qingdao University;
September 1997-July 2000, Doctor of Medical Science, Fudan University;
October 2000-October 2002, Postdoctoral Fellow, Weizmann Institute of Science (Israel);
November 2002-August 2006, Postdoctoral Fellow, University of Calgary (Canada);
Since September 2006, selected into CAS Hundred Talents Program, and professor at School of Life Sciences, University of Science and Technology of China
We are currently investigating the molecular etiology and mechanisms of male infertility, especially elucidating the roles of non-coding RNAs such as microRNAs, piRNAs on spermatogenesis. On the other hand, we are interested in exploring the potential regulation of non-coding RNAs on spermatogenic stem cells.
1.Liang N, Xu YL, Yin YM, Yao GD, Tian H, Wang GS, Lian J, Wang Y, and Sun F. Steroidogenic Factor-1 Is Required for TGF-β3-Mediated 17β-Estradiol Synthesis in Mouse Ovarian Granulosa Cells. Endocrinology 2011, doi:10.1210/en.2011-0102
2.Lian J, Tian H, Liu L, Zhang XS, Li WQ, Deng YM,Yao GD, Yin MM, Sun F. Down-regulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. Cell Death Dis 2010, 1, e94; doi:10.1038/cddis.2010.70. Highlighted in Cell Death Dis.
3.Yao GD, Yin MM, Lian J, Tian H, Liu L, Li X, Sun F . MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cel1 proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol, 2010, 24(3): 540-551.
4.Lian J, Zhang XS, Tian H, Liang N, Wang Y, Liang CZ, Li X, Sun F. Altered microRNA expression in patients with non-obstructive azoospermia. Reprod Biol Endocrinol 2009, 7:13.
5.Lian J, Yin YM, Oliver-Bonet M, Liehr T, Ko E, Turek P, Sun F, Martin RH. Variation in crossover interference levels on individual chromosomes from human males. Hum Mol Genet 2008, 17(17): 2583-2594. Highlighted as cover illustration.