University of Science and Technology of China
B.S. Physics, Beijing University, Beijing, China, 1985–1989
Ph.D. Molecular and CellBiology, University of California at Berkeley, CA, 1993–1999
Postdoctoral fellow Neurobiology, University of California at San Diego, CA, 1999–2000
We are interested in the development and function of neuronal circuits that are the building blocks of brain physiology. In particular, we focus on a particular form of reverberatory activity that we first observed in cultured neurons. We are using electriphysiological and optical methods to study such collective network activity in vitro and in vivo, aiming at understanding the mechanisms of its emergence and evolution as well as its relevance in brain functions and related disorders.
1.Lau, P.-M., Zucker, R. S. & Bentley, D. (1999) Induction of filopodia by direct local elevation of intracellular calcium ion concentration. J Cell Biol 145:1265-75.
2.Lau, P.-M. & Bi, G. Q. (2005) Synaptic mechanisms of persistent reverberatory activity in neuronal networks. Proc Natl Acad Sci U S A 102:10333-8.
3.*Gerkin, R. C., *Lau, P.-M., Nauen, D. W., Wang, Y. T. & Bi, G.-Q. (2007) Modular Competition Driven by NMDA Receptor Subtypes in Spike-Timing-Dependent Plasticity. J Neurophysiol 97:2851-2862.
4.Volman, V., Gerkin, R. C., Lau, P.-M., Ben-Jacob, E. & Bi, G.-Q. (2007) Calcium and synaptic dynamics underlying reverberatory activity in neuronal networks. Phys Biol 4:91-103.
5.Lau, P.-M*. & Bi, G.-Q. (2009) Reverberatory activity in neuronal networks: synaptic mechanisms, dynamics and plasticity. In Coherent Behavior in Neuronal Networks, Ed, Rubin, J.E., et al., Springer (*Corresponding author)
6.Zhang JC, Lau PM, Bi GQ. (2009) Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses. Proc Natl Acad Sci U S A. 106:13028-33
7.*Stauffer WR, *Lau PM, Bi GQ, Cui XT. (2011) Rapid modulation of local neural activity by controlled drug release from polymer-coated recording microelectrodes. J Neural Eng. [Epub ahead of print]