SHAN Ge
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    SHAN Ge

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    Professor of School of Life Sciences

    University of Science & Technology of China

    Tel: 86-551-63606274

    Fax:86-551-63606274

    e-mail: shange@ustc.edu.cn

    Hmepage:

      Personal Profile

    a)Bachelor of Science, Department of Biology, Lanzhou University, China. 1995

    b)M.S. in Developmental Biology, Shanghai Institute of Cell Biology, Chinese Academy of Sciences, 1998

    c)Ph.D. in Neurobiology and Behavior program, Department of Biology, Georgia State University, Degree awarded in 2005.

    Working experience

    2005-2008  Postdoctoral Fellow, Department of Human Genetics, Emory University, school of medicine; mentor: Dr. Peng Jin.

    March, 2008- Postdoctoral Associate, Department of Molecular, Cellular and Developmental Biology, Yale University; Mentor: Dr. Sidney Altman (Nobel laureate in Chemistry, 1989).

    Research Interests

    My lab is interested in the function and regulation of noncoding RNAs (ncRNAs). ncRNAs play essential and many known and unknown roles in animal development, cellular processes, diseases, and epigenetics. We utilize models such as C. elegans, mammalian cell cultures, and mice to explore roles of ncRNAs. We pay particular attention to the possible regulation of gene expression by environmental ncRNAs, roles of natural antisense RNAs, and functions of ncRNAs in stem cells and neuronal differentiation. 

    Selected Publications

    10, Luo Y*, Shan G*, Guo W*, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X.*Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult NeuralStem/ProgenitorCells. PLOS Genetics 2010, 6(4): e1000898.

    9, Ge Shan#. RNA interference as gene knockdown technique. The International Journal of Biochemistry & Cell Biology 2010, 42(8):1243-51.

    8, N. Shen*, J. Ko*, G. Xiao*, D. Wesolowski, G. Shan, B. Geller, M. Izadjoo, S. Altman. Inactivation of expression of several genes in a variety of bacterial species by the EGS technology. P.N.A.S., 2009, 106(20): 8163-8.

    7, Shan G. and Jin P. RNA Interference to Treat Human Diseases. Volume 4 pp 241-251. In Wiley Encyclopedia of Chemical Biology. 2009, John Wiley & Sons, Hoboken.

    6, G. Shan, Y. Li, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, Chan AW, Shi Z, Liu Q, Wahlestedt C, He C, Jin P. A small molecule enhances RNA interference and promotes the biogenesis of microRNAs. Nature Biotechnology. 2008, 26(8):933-40.

    5, G. Shan, Walthall WW. Copulation in Caenorhabditis elegans requires a Nuclear Hormone Receptor. Developmental Biology. 2008, 322(1):11-20.

    4, G. Shan, S. Xu, P. Jin. FXTAS: a bad RNA and a hope for a cure. Expert Opinion on Biological Therapy. 2008, 8(3):249-53.

    3, D. C. Zarnescu, G. Shan, S. T. Warren, P. Jin. Come FLY with us: toward understanding fragile X syndrome. Genes, Brain and Behavior. 2005, 4(6):385-92.

    2, Shan G, Kim K, Li C, Walthall WW. Convergent genetic programs regulate similarities and differences between related motor neuron classes in Caenorhabditis elegans. Developmental Biology. 2005, 280(2): 494-503.

    1, Xu H, Yang Z, Cui N, Giwa LR, Abdulkadir L, Patel M, Sharma P, Shan G, Shen W, Jiang C. Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels. Am J Physiol Cell Physiol. 2000, 279(5):C1464-71.

     

    *co-first authors; # corresponding author

     

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