TU Xiaoming


Associate Professor of School of Life Science

University of Science & Technology of China


Tel: 86-551-63600757


e-mail: xmtu@ustc.edu.cn


  Personal Profile

2005-to-date  School of Life Science, USTC      Associate Professor

2002-2005   University of California, San Francisco   Post-doc.

1997-2002   School of Life Science, USTC       Ph.D.

1993-1997   School of Life Science, USTC       B.S.

Research Interests

We are attempting to study the structure and function of a number of proteins involved in a variety of cellular events. Currently, we are focusing on elucidation of the structure, function and their relationship of ubiquitin-like family proteins from eukaryote, prokaryote and archaea.

We are also attempting to elucidate the molecular mechanism of cell cycle regulation and gene expression regulation in Trypanosoma brucei. We are currently focusing on the two PWWP domain containing proteins involved in the gene expression regulation.  

Selected Publications

1.Kun Dai, Shanhui Liao, Jiahai Zhang, Xuecheng Zhang and Xiaoming Tu (2011) Solution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1. PLoS ONE. In press.

2.Wen Zhang, Jiahai Zhang, Xuecheng Zhang, Chao Xu and Xiaoming Tu (2011) Solution structure of Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae. Biochemical Journal. 436: 83-90.

3.Shanhui Liao, Tao Wang, Kai Fan and Xiaoming Tu (2010) The small ubiquitin like modifier is essential in regulating mitosis in Trypanosoma brucei. Experimental Cell Research. 316: 704-715.

4.Shanhui Liao, Qiang Shang, Xuecheng Zhang, Jiahai Zhang, Chao Xu and Xiaoming Tu (2009) Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein. Biochemical Journal. Accelerated Publication. 422: 207-215.

5.Wen Zhang, Jiahai Zhang, Chao Xu, Tao Wang, Xuecheng Zhang and Xiaoming Tu (2009) Solution structure of Urm1 from Trypanosoma brucei. Proteins: Structure, Function, and Bioinformatics. 75:781-785.

6.Qiang Shang, Cao Xu, Jiahai Zhang, Xuechen Zhang and Xiaoming Tu (2009) Solution Structure of SUMO from Trypanosoma brucei and Its Interaction with Ubc9. Proteins: Structure, Function, and Bioinformatics . 76:266-269.

7.Xiaoming Tu, Praveen Kumar, Ziyin Li and Ching C. Wang (2006) An Aurora Kinase Homologue is Involved in Mitosis and Cytokinesis in Trypanosoma brucei. J. Biol. Chem. 281:9677-9687.

8.Xiaoming Tu, Joel Mancuso, W. Zacheus Cande and Ching C. Wang (2005) Distinct Cytoskeletal Modulations and Mechanisms Regulating G1/S Transition between Two Life Stages of Trypanosoma brucei Cytoskeletal. Journal of Cell Science. 118:4353-4364.

9.Xiaoming Tu and Ching C. Wang (2005) Coupling of Posterior Cytoskeletal Morphogenesis to the G1/S Transition in the Trypanosoma brucei Cell Cycle. Molecular Biology of the Cell. 16:97-105.

10.Xiaoming Tu and Ching C. Wang (2004) The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion. J. Biol. Chem. 279:20519-20528.