2011.02.20,published online in China University of

  • [2011-07-08]
  • Internationally renowned academic journal "Nature: Cell Biology" (Nature Cell Biology) 2011.02 .20published online in China University of Science and Technology College of Life Sciences Professor Wu Mian and the University of Pennsylvania School of Medicine Professor Yang Xiaolu cooperative research "p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase ". Tumor suppressor p53 in the regulation of the pentose phosphate pathway (pentose phosphate pathway, PPP) has played an important role. cells, p53 is by far the most important tumor suppressor, one of its growth and development of the cell cycle regulation, DNA repair and apoptosis, and other important cellular processes play a key role. In recent years, found that p53 in cell metabolism, especially in sugar metabolism also plays an important role. Wu and Yang Lu Myanmar laboratory research group's work proved that p53 can pentose phosphate pathway the first step on the reaction of a key enzyme glucose-6 - phosphate dehydrogenase (glucose-6-phosphate dehydrogenase, G6PD) combined, and the inhibition of its activity. Under normal circumstances, p53 in this pathway to prevent cells in the glucose so it is mainly used for glycolysis and the citric acid cycle; in p53 mutations or deletions of tumor cells, because loss of p53 mutations in it the ability to bind with G6PD and G6PD inhibition, cells use glucose, another metabolic pathway that is the pentose phosphate pathway so accelerated, large consumption of glucose, which partly explains the 20 years since the late 19th century, scientists made the phenomenon of Warburg (Warburg effect). In addition, because the PPP accelerated, resulting in a large number of NAPDH and pentose (DNA group were raw materials) to meet the rapid growth of tumor cells required for a large number of DNA replication. The study also the first time: p53 in addition to transcriptional activity, but also has a catalytic function, it is combined with the instantaneous substrate in order to "hit-and-run" mode of the G6PD enzyme activity was reduced. Nature Cell Biology News and Views in the same period in the form of a lengthy comment on "p53 guards the metabolic pathway less travelled". First author is a doctoral student Wu Burma laboratory and Du Wenjing Jiang Peng, currently in the USA University of Pennsylvania School of Medicine post-doctoral research either. The research was supported by Foundation of Life Science, Chinese Academy of Sciences and Ministry of Science funding