2012.10.17,Professor Sun Baoling Published a paper in International Journal of Antimicrobial Agents, online

  • 2012.10.17,Professor Sun Baoling Published a paper entitled “LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC8325” in International Journal of Antimicrobial Agents, online
    Author:Xue Ting,Zhao Liping,Sun Baoling

    DOI: 10.1016/j.ijantimicag.2012.08.016

    Abstract

      Current treatment for Staphylococcus aureus infections relies heavily upon the cell wall synthesis inhibitor antibiotics such as penicillin, oxacillin, vancomycin and teicoplanin. Increasing antibiotic resistance requires the development of new approaches to combating infection. Autoinducer-2 (AI-2) exists widely both in Gram-negative and Gram-positive pathogens and is suggested as a universal language for intraspecies and interspecies communication. This study demonstrates the association between AI-2 signalling and cell wall synthesis inhibitor antibiotic susceptibility in S. aureus. In addition, a luxS mutant exhibited decreased autolysis and upregulated vancomycin resistance-associated VraRS two-component regulatory system. This finding may provide novel clues for antimicrobial therapy in S. aureus infection.

     

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