2011.04.12,Professors Yao Xuebiao and Song Erwei Published a paper entitled “ ancer Cell CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM 3” in Cancer Cell

  • Author:Chen Jingqi、Yao Yandan、Gong Chang、Yu Fengyan、Su Shicheng、Chen Jianing、Liu Bodu、Deng HUi、Wang Fengsong、Lin Lin、Yao Herui、Su Fengxi、Karen Anderson、Liu Qiang、Mark Ewen、Yao Xuebiao、Song Erwei 

    Abstract

    Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis, but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival. CCL18 released by breast TAMs promotes the invasiveness of cancer cells by triggering integrin clustering and enhancing their adherence to extracellular matrix. Furthermore, we identify PITPNM3 as a functional receptor for CCL18 that mediates CCL18 effect and activates intracellular calcium signaling. CCL18 promotes the invasion and metastasis of breast cancer xenografts, whereas suppressing PITPNM3 abrogates these effects. These findings indicate that CCL18 derived from TAMs plays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.

     

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