2011.04.04,Professor Wang Jun Published a paper in ACS Nano

  • 2011.04.04,Professor Wang Jun published a paper entitled “xorubicin-Tethered Responsive Gold Nanoparticles Facilitate IntracellularDrugDelivery for Overcoming MultidrugResistancein Cancer Cells”in ACS Nano
    Author:Feng Wang, Yu-Cai Wang, Shuang Dou, Meng-Hua Xiong, Tian-Meng Sun, and Jun Wang

    Abstract

    Multidrugresistance(MDR) is a major impediment to the success of cancer chemotherapy. Through the development of adrugdelivery system that tethers doxorubicin onto the surface of gold nanoparticles with a poly(ethylene glycol) spacerviaan acid-labile linkage (DOX-Hyd@AuNPs), we have demonstrated that multidrugresistancein cancer cells can be significantly overcome by a combination of highly efficient cellular entry and a responsive intracellular release of doxorubicin from the gold nanoparticles in acidic organelles. DOX-Hyd@AuNPs achieved enhanceddrugaccumulation and retention in multidrug resistant MCF-7/ADR cancer cells when it was compared with free doxorubicin. It released doxorubicin in response to the pH of acidic organelles following endocytosis, opposite to the noneffective drugrelease from doxorubicin-tethered gold nanoparticles via the carbamate linkage (DOX-Cbm@AuNPs), which was shown by the recovered fluorescence of doxorubicin from quenching due to the nanosurface energy transfer between the doxorubicinyl groups and the gold nanoparticles. DOX-Hyd@AuNPs therefore significantly enhanced the cytotoxicity of doxorubicin and induced elevated apoptosis of MCF-7/ADR cancer cells. With a combined therapeutic potential and ability to probedrugrelease, DOX-Hyd@AuNPs represent a model with dual roles in overcoming MDR in cancer cells and probing the intracellular release ofdrug from its delivery system. (DOI: 10.1021/nn200007z)

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