LIU Suling

  • Suling Liu, Ph.D.

    Professor

    School of Life Sciences University of Science & Technology of China

    Tel: +86 551-63606932

    Fax: +86 551-63606932

    e-mail: suling@ustc.edu.cn

    Homepage:http://staff.ustc.edu.cn/~suling/index_ie.htm

    Personal Profile

    · Jun. 2012-Present, Professor, School of Life Sciences, University of Science & Technology of China

    · Oct. 2010~Jun. 2012, Assistant Professor, Comprehensive Cancer Center, University of Michigan, Ann Arbor, USA.    

    · Oct. 2006~Oct. 2010, Research Investigator, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.    

    · Oct. 2003~Sept. 2006, Research Fellow, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.    

    · Jan. 1998~Sept.2003, Graduate Research Assistant, Department of Veterinary Biosciences, The Ohio State University

    Research Interests


     

    1. Identifying different states of breast stem cells to develop the novel combination therapies targeting different breast cancer stem cells.
    2. Investigating the combination therapy of PARPi and 17-AAG to target cancer stem cells in Triple-negative breast cancers.
    3. Studying the effects of microRNAs on breast cancer stem cell self-renewal and differentiation, and develop some miRNA-based therapies with nanotechnology.
    4. Studying the tumor microenvironment in regulating breast cancer stem cells.

      Honors and Awards

    · Idea award from U.S. Department of Defense 2012

    · Susan G Komen Career Catalyst research award 2011

    · AACR‑Susan G. Komen Scholar‑in‑Training Award 2010

    · AACR-Merck Scholar-in-Training Award 2006

    · Research Fellowship from the Susan G. Komen Breast Cancer Foundation 2005-2008

    · Graduate Research Associate Scholarship from the Ohio State University 1999-2003

    · Coca Cola Critical Difference for Women Dissertation Grant 2002-2003

    · Travel Award from Program of Enhancement funds for Graduate Students 2001

    · Professional Development Fund Travel Award from the Council of Graduate Students of the Ohio State University 2001

    Selected Publications (15 out 40)

    1.S. Liu*, S.H. Patel, C. Ginestier, I. Ibarra, R. Martin-Trevino, S. Bai, S. McDermott, L. Shang, J. Ke, S.J. Ou, A. Heath, K.J. Zhang, H. Korkaya, S.G. Clouthier, E. Charafe-Jauffret, D. Birnbaum, G.J. Hannon, and M.S. Wicha. MicroRNA93 Modulates Breast Cancer Stem Cells by Regulating their EMT/MET States, Proliferation and Differentiation. PlosGenetics 8(6), 2012. (*Corresponding Author). PMID: 22685420

    2.S. Liu, H Korkaya, M.S. Wicha. Are cancer stem cells ready for prime time? The Scientist. April 1, 2012.

    3.S. Liu, S.G. Clouthier, M.S. Wicha. Role of microRNAs in the regulation of breast cancer stem cells. Journal of mammary gland biology and neoplasia17(1):15-21, 2012.

    4.S. Liu*, C. Ginestier, S.J. Ou, S.G. Clouthier, S.H. Shivani, F. Monville, H. Korkaya, A. Heath, J. Dutcher, C. Kleer, Y. Jung, G. Dontu, R. Taichman, M.S. Wicha*. Mesenchymal stem cells regulate breast cancer stem cells defining a cancer stem cell niche. Cancer Res 71(2); 614–24, 2011. (Cover featured, *Corresponding Author). PMID: 21224357

    5.H. Korkaya, S. Liu, M.S. Wicha. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. Journal of Clinical Investigation. 2011 Oct 3;121(10):3804-9.PMID: 21965337

    6.S. Liu, M. S. Wicha. Targeting breast cancer stem cells. Journal of Clinical Oncology 28(25): 4006-4012, 2010. PMID: 20498387

    7.Y. Li, T. Zhang, H. Korkaya, S. Liu, H.F. Lee, B. Newman, Y. Yu, S.G. Clouthier, S.J. Schwartz, M.S. Wicha, and D. Sun. Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells. Clinical Cancer Research 16(9):2580-90, 2010. PMID: 20388854

    8.C. Ginestier, S. Liu, M.E. Diebel, H. Korkaya, M. Luo, J. Dutcher, M. Brown, E. Charafe-Jauffret, D. Birnbaum, J.L. Guan, G. Dontu, M.S. Wicha. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. JCI120(2):485-97, 2010. PMID: 20051626

    9.C. Ginestier, S. Liu, M.S. Wicha. Getting to the root of BRCA1-deficient breast cancer. Cell Stem Cell 5 (3): 229-230, 2009. PMID: 19733528

    10.G Deniz, S. Liu, M.S. Wicha, A. Shukla, D Krag. Identification of Single Chain Antibodies to Breast Cancer Stem Cells Using Phage Display. Biotechnology progress 25(6):1780-7, 2009. PMID: 19899107

    11.S. Liu, C. Ginestier, E. Charafe-Jauffret, H. Foco, C.G. Kleer, S.D. Merajver, G. Dontu, M.S. Wicha. BRCA1 Regulates Human Mammary Stem/Progenitor Cell Fate. PNAS (USA) 105 (5): 1680-1685, 2008. PMID: 18230721

    12.C. Ginestier, M.H. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, M. Brown, J. Jacquemier, P. Viens, C.G. Kleer, S. Liu, A. Schott, D. Hayes, D. Birnbaum, M.S. Wicha, D. Dontu. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1: 555-567, 2007. PMID: 18371393

    13.S. Liu, G. Dontu, I. Mantle, S. Patel, N. Ahn, K.W. Jackson, P. Suri, and M.S. Wicha. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research 66: 6063-6071, 2006. PMID: 16778178

    14.M.S. Wicha, S. Liu, and G. Dontu. Cancer Stem Cells: An Old Idea--A Paradigm Shift. Cancer Research 66(4): 1883-1890, 2006. PMID: 16488983

    15.S. Liu, G. Dontu, and M.S. Wicha. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast cancer research 7(3): 86-95, 2005. PMID: 15987436