CANG Chunlei
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    CANG Chunlei

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    Chunlei Cang
    Professor,
    School of Life Sciences
    University of Science & Technology of China
    Hefei, China
    Tel: (+86) 18655123362
    E-mail: ccang@ustc.edu.cn

    Personal profile
    2015 – Present:  Professor, School of Life Sciences, University of Science & Technology of China, China
    2009 – 2014: Postdoc, Department of Biology, University of Pennsylvania, US
    2003 – 2009: Ph.D., Institute of Neurobiology, Fudan University, China
    1999 – 2003: B.Sc., School of Life Sciences, Fudan University, China

    Research interests
    Properties, functions and modulation of intracellular ion channels, especially the ones exist on membrane of lysosome and endosome.

    Publications:
    1.Cang, C., Aranda, K., Seo, YJ., Gasnier, B., Ren, D. (2015) TMEM175 is an Organelle K(+) Channel Regulating Lysosomal Function. Cell 162(5): 1101-12. Doi:10.1016/j.cell.2015.08.002
    2.Cang, C., Zhou, Y., Navarro, B., Aranda, K., Shi, L., Battaglia-Hsu, S., Nissim, I., Clapham, D. and Ren, D. (2013) mTOR Regulates Lysosomal ATP-sensitive Two-Pore Na+ Channels to Adapt to Metabolic State. Cell 152: 778-790
    3.Cang, C.*, Aranda, K., Ren, D.*. A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability. Nature communications 5: 5015 (*co-corresponding authors)
    4.Cang, C.*, Bekele, B., Ren, D.*. (2014) The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nature Chemical Biology 10: 463-469 (*co-corresponding authors)
    5.Cang CL, Zhang H, Zhang YQ, Zhao ZQ (2009) PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Mol Pain 5:33
    6.Zhang H., Cang CL, Kawasaki Y, Liang LL, Zhang YQ, Ji RR, Zhao ZQ (2007) Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKC: a novel pathway for heat hyperalgesia. J Neurosci 27: 12067-12077
    7.Xu SY, Cang CL, Liu XF, Peng YQ, Ye YZ, Zhao ZQ, Guo AK (2006) Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene. Genes Brain Behav 5: 602–613

     

     

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