LIU Dan Ph.D.
2001-2007 PH.D., Biology, University of Science and Technology of China
1997-2001 B.S., Biology, University of Science and Technology of China
2013- Professor, Cell Biology, University of Science and Technology of China.
2007-2012 Postdoctoral research with Professor Michael A. Lampson, University of Pennsylvania. Focus on revealing regulation mechanisms of kinetochore-microtubule attachments by mitotic kinases and phosphatases.
2005-2006 Visiting study with Professor Kunio Takeyasu, Kyoto University. Focus on Studying macromolecule structures by Atomic force microscopy.
2001-2007 Ph.D. research with Professor Xuebiao Yao, University of Science and Technology of China. Focus on identifying kinetochore motor protein CENP-E’s binding proteins and functions.
Membership and Honorship
2008-2011 Member of American Society of Cell Biology
2012 The work published on Science, 2009 “Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.” was included by “Molecular Cell Biology” 7th edition.
2013 Scholar of Youth 1000 talents plan.
Conference and Presentations:
2011 Presentation: Regulation of kinetochore-microtubule dynamics and spindle checkpoint silencing by Polo-like kinase-1, in 51th American Society of Cell Biology annual meeting.
2010 Attendee of 50th American Society of Cell Biology annual meeting.
2008 Presentation: Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates, in 48th American Society of Cell Biology annual meeting.
Liu D., Davydenko O., Lampson M.A. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. J Cell Biol. 2012 Aug; 198:491-499.
Welburn J.P., Vleugel M., Liu D., Yates III J.R., Lampson M.A., Fukagawa T., Cheeseman I.M. Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface. Mol. Cell. 2010 May; 38:383-392.
Liu D., Vleugel M., Backer C.B., Hori T., Fukagawa T., Cheeseman I.M., Lampson M.A. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol. 2010 March; 188:809-820.
Liu D., Vader G., Vromans M.J., Lampson M.A., Lens S.M. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009 Mar; 323:1350-1353.
Liu D., Ding X., Du J., Cai X., Huang Y., Ward T., Shaw A., Yang Y., Hu R., Jin C., Yao X. Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. J Biol Chem. 2007 July; 282:21415-21424.
Liu D.†, Ge L.†, Wang F., Takahashi H., Wang D., Guo Z., Yoshimura S.H., Ward T., Ding X., Takeyasu K., Yao X. Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation. FEBS Lett. 2007 Jul; 581:3563-3571. († equal contribution)
Liu D., Zhang N., Du J., Cai X., Zhu M., Jin C., Dou Z., Feng C., Yang Y., Liu L., Takeyasu K., Xie W., Yao X. 2006. Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis. Biochem Biophys Res Commun. 2006 Apr; 345:394-402.
Xue Y.†, Liu D.†, Fu C., Dou Z., Zhou Q., Yao X. A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins. Chinese Science Bulletin. 2006 Aug; 51:1836-1847. († equal contribution)
Liu D., Lampson M.A. Regulation of kinetochore-microtubule attachments by Aurora B kinase. Biochem Soc Trans. 2009 Oct; 37(5):976-980.
Liu D., Jin C., Yao X. Progress and perspective of the kinetochore-associated motor proteins. Chinese Science Bulletin. 2003 Jan; 48(2):111-117.