2014.03.28,Professor Shi Yunyu/Wu Jihui Published a paper entitled:“Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding” in Cell Research,online
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    2014.03.28,Professor Shi Yunyu/Wu Jihui Published a paper entitled:“Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding” in Cell Research,online


  • Author:Wang Juncheng、Qin Su、LI Fudong、Li Sai、Zhang Wei、Peng Junhui、Zhang Zhiyong、Gong Qingguo、Wu Jihui、Shi Yunyu
    Abstract:The eukaryotic genome is packed into highly compacted chromatin, the basic unit of which is a nucleosome composed of 147 base pairs of DNA wrapped around the histone octamer. Post-translational modifications along histone N-terminal tails can be recognized by various 'reader' modules. PWWP domain, one type of 'reader' modules, has been identified to recognize H3K36me3 in the peptide and nucleosome context.
    http://dx.doi.org/10.1038/cr.2014.38



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