Professor & Chair, Department of Systems Biology
School of Life Sciences
University of Science & Technology of China
Dr. Jia-Rui Wu graduated in Dept. of Biology of Zhongshan University in Guangzhou in 1982, received a master degree from Institute of Genetics of Chinese Academy of Sciences in Beijing in 1985, and a doctor degree from Swiss Federal Institute of Technology in Zurich in 1994. He was a postdoctoral fellow in Health Science Center of State University of New York from 1994-1997. Since then, he become a professor in Shanghai Institute of Biochemistry in Chinese Academy of Sciences in Shanghai. Now he is a vice-president of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and the chair of Department of Systems Biology, University of Science and Technology of China.
My Lab has concentrated on two major topics in the areas of systems biology. First, we are interested in the structure and function of molecular networks for cell fate determination among cell differentiation, cell proliferation and apoptosis, particularly I would like to ask that how cells inter-regulate cell proliferation and differentiation, which is a key to understand the behaviors of stem cells and the development of multi-cellular organisms.
Secondly, we are interested in the analysis of the complex diseases such as cancer and diabetes based on the research strategy of systems biology. We have developed systematic approaches based on proteomics and bioinformatics to analyze human normal and diabetic serum. In addition, I have planed to analyze the genetic and environmental factors and their interactions during the progressing of the type 2 diabetes.
1.Hongjuan Pei ,Yao Yao, Ying Yang, Kan Liao* and Jiarui Wu*. Krüppel-like factor KLF9 regulates PPARgamma transactivation at the middle stage of adipogenesis.Cell Death Differ, 2011, 18:315-327.
2.Zhi Liang*, Meng Xu, Maikun Teng, Liwen Niu,Jiarui Wu* Coevolution is a short-distance force at the protein interaction level and correlates with the modular organization of protein networks. FEBS Letter 2010, 584:4237-4240
3.W Guo, KM Zhang, K Tu, YX Li, L Zhu, HS Xiao, Y Yang, JR Wu* Adipogenesis licensing and execution are disparately linked to cell proliferation Cell Res. 2009, 19:216-223
4.RX Li, HB Chen, K Tu, SL Zhao, H Zhou, SJ Li, J Dai, QR Li, S Nie, YX Li, WP Jia*, R Zeng*,JR Wu*Localized-Statistical Quantification of Human Serum Proteome Associated with Type 2 DiabetesPLoS ONE 2008, 3:e3224
5.Lei Xiong, Fei Kou, Ying Yang, and Jiarui Wu*A novel role for IGF-1R in p53-mediated apoptosisthrough translational modulation of the p53-Mdm2 feedback loop J. Cell Biol. 2007, 178:995-1007.
6.Q Sheng, LS Wang, J Dai, XS Jiang, RX Li, DJ Ma, YX Li, R Zeng*, JR Wu*Comparison of a proteomic approach with a microarray-based approach to detect exons in the mouse genome. Nat Genet. 2006, 38:1223-1224.
7.Jianbei Zhu, Lei Xiong, Biao Yu , and Jiarui Wu* Apoptosis induced by a new member of saponin family is mediated through caspase-8 dependent cleavage of Bcl-2 Mol. Pharmacol. 2005, 68:1831–1838.
8.Xiao-Sheng Jiang, Liu-Ya Tang, Jie Dai, Hu Zhou, Su-Jun Li,Qi-Chang Xia, Jiarui Wu*, Rong Zeng* Quantitative analysis of SARS-coronavirus infected cells using proteomic approaches: Implications for cellular responses to virus infection. Mol Cell Proteomics. 2005, 4:902-913.
9.Man-Rong Jiang, Yuan-Chao Li, Ying Yang, Jiarui Wu* c-Myc degradation induced by DNA damage results in apoptosis of CHO cells，Oncogene2003, 22: 3252–3259.
10.Zilong Qiu, Yong Wei, Nan Chen, Manrong Jiang, Jiarui Wu*, Kan Liao* DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocytes differentiation into adipocytes, J. Biol. Chem. 2001, 276:11988-11995.