Professor, Member of Chines Academy of Science
School of Life Sciences
University of Science & Technology of China
EDUCATION AND RESEARCH EXPERIENCE
1960-1965, Biophysics, Department of Physics, University of Science and Technology of China (USTC)
1965-1970, Assistant researcher, Chinese traditional medicine institute，Beijing
1970- Assistant professor, Lecturer, Associate professor, Professor USTC,
1979-1981, Visiting scholar, Department of Chemistry of Roma University and CNRS Lab. of Structural Chemistry, Italy;
1985 & 1990, Visiting Scholar, Department of Chemistry, University of Groningen, Netherlands.
1994, Visiting Scholar, CNRS Lab of Structural Biology, Gif-Yvette, France.
1996, Visiting Scholar, CNRS Lab of Theoretical Chemistry, University of NANCY, France.
1997, Member of the Chinese Academy of Sciences (CAS)
2003, Fellow of TWAS (the academy of sciences for the developing world)
Our laboratory is interested in epigenetic regulation of gene expression, especially histone modifications, chromatin remodeling, histone chaperone, and ncRNA regulation. We are also interested in noncoding RNA interaction with Protein. We use structural biology methods to study structure, dynamics, and function of protein, RNA, and their interactions in epigenetic regulation process
REPRESENTATIVE PUBLICATIONS (*: corresponding author)
1)Wang W, Wang L, Zou Y, Zhang J, Gong Q, Wu J, Shi Y*. Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes and Development 2011; 25(19):2106-17.
2)Qiu Y, Liu L, Zhao C, Han C, Li F, Zhang J, Wang Y, Li G, Mei Y, Wu M, Wu J*, Shi Y*. Combinatorial Readout of Unmodified H3R2 and Acetylated H3K14 by the Tandem PHD Finger of MOZ Reveals a Regulatory Mechanism for HOXA9 Transcription. Genes and Development. 2012, 26(12):1376-91.
3)He C., Pillai S. S., Taglini F., Li F., Ruan K., Zhang J., Wu J., Shi* Y., and Bayne* E. H., A novel tandem zinc finger domain in Stc1: structural insights into the coupling of RNAi and chromatin modification, Proc Natl Acad Sci U S A , 2013 May 21;110(21):E1879-88
4)Li S, Wandel MP, Li F, Liu Z, He C, Wu J, Shi* Y, Randow F*. Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy. Sci. Signal. 2013 Feb 5;6(261):ra9. doi: 10.1126/scisignal.2003730.（被F1000推荐）
5)He C., Li F., Zhang J., Wu J*., Shi Y*., The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD family members in their histone H3 recognition, J. Biol. Chem., 2013, 288(7):4692-703.
6）Wang L, Wang W, Li F, Zhang J, Wu J, Gong Q*, Shi Y*. Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq. Nucleic Acids Res. 2015, 43(4):2400-11.
7）Liu Z, Li F, Zhang B, Li S, Wu J*, Shi Y*. Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. J Biol Chem. 2015，290(10)，6630-8
8)Li F, Zhao D, Wu J*, Shi Y*. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. , Cell Res. 2014 Dec;24(12):1490-2.
9）Wang C, Zhu Y, Caceres TB, Liu L, Peng J, Wang J, Chen J, Chen X, Zhang Z, Zuo X, Gong Q, Teng M, Hevel JM, Wu J*, Shi Y*. Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7 , Structure. 2014, 22(5):756-68.
10）Wang J, Qin S, Li F, Li S, Zhang W, Peng J, Zhang Z, Gong Q, Wu J*, Shi Y*. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosomes binding. Cell Res. 2014.24, 890-3 2014.38.
11）Liu Z, Li F, Ruan K, Zhang J, Mei Y, Wu J*, Shi Y*, Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6. J Biol Chem. 2014, 289(14):10069-83
12) Wang L., Wang W, Li F., Zhang J, Wu J., Gong*Q. and Shi*Y. ,Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq. Nucleic Acids Research (2015) 43(4):2400-2411.
13) Liu Z., Li F., Zhang B., Li S., Wu J.,* and Shi* Y., Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. Journal of Biological Chemistry (2015) 290:6630-6638.
14) Wang C, Zhu Y, Bao H, Jiang Y, Xu C, Wu J*, Shi Y*.A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1., Nucleic Acids Res. 2015 Dec pii: gkv1382. [Epub ahead of print]